{"id":113751,"date":"2023-03-16T16:47:15","date_gmt":"2023-03-16T15:47:15","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=113751"},"modified":"2023-05-04T11:42:36","modified_gmt":"2023-05-04T09:42:36","slug":"can-psilocybin-treat-chronic-pain-in-veterans","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/cs\/blog\/can-psilocybin-treat-chronic-pain-in-veterans\/","title":{"rendered":"M\u016f\u017ee psilocybin l\u00e9\u010dit chronickou bolest u veter\u00e1n\u016f?"},"content":{"rendered":"

\u00a0<\/strong><\/p>\n\n\n\n

Veter\u00e1ni se st\u00e1vaj\u00ed objekty psychedelick\u00e9ho v\u00fdzkumu<\/h2>\n\n\n\n

Kv\u016fli t\u011bmto pot\u00ed\u017e\u00edm jsou veter\u00e1ni nejv\u00edce ohro\u017eeni dvoj\u00ed hrozbou - z\u00e1vislost\u00ed na opioidech a smrt\u00ed z p\u0159ed\u00e1vkov\u00e1n\u00ed. D\u00edky tomu v\u0161ak maj\u00ed tak\u00e9 jedine\u010dn\u00e9 postaven\u00ed v \u010dele v\u00fdzkumu, kter\u00fd ukazuje, \u017ee psychedelika mohou b\u00fdt zp\u016fsobem, jak \u00fa\u010dinn\u011bji l\u00e9\u010dit chronickou bolest. A na rozd\u00edl od opioid\u016f bez rizika p\u0159ed\u00e1vkov\u00e1n\u00ed nebo z\u00e1vislosti. <\/p>\n\n\n\n

\"\"
Foto: Filip Andrejevic na Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Psychedelick\u00e1 renesance v posledn\u00edm desetilet\u00ed s\u00edl\u00ed a Nemocnice VA<\/a> v USA se staly p\u0159ekvapiv\u00fdm epicentrem kontrolovan\u00fdch psychedelick\u00fdch test\u016f. V t\u011bchto studi\u00edch se psychedelika, jako je psilocybin z magick\u00fdch hub, pou\u017e\u00edvaj\u00ed k l\u00e9\u010db\u011b stav\u016f, jako je nap\u0159. PTSD<\/a>, deprese a \u00fazkost. D\u016fvody jsou dva: zaprv\u00e9 proto, \u017ee veter\u00e1ni jsou k t\u011bmto stav\u016fm n\u00e1chyln\u011bj\u0161\u00ed. A za druh\u00e9 proto, \u017ee nemocnice VA jsou kontrolovan\u00fdm prost\u0159ed\u00edm, kter\u00e9 je pro prov\u00e1d\u011bn\u00ed t\u011bchto typ\u016f studi\u00ed ide\u00e1ln\u00ed. <\/p>\n\n\n\n

D\u00edky t\u011bmto studi\u00edm ji\u017e existuj\u00ed p\u0159esv\u011bd\u010div\u00e9 p\u0159edb\u011b\u017en\u00e9 \u00fadaje o \u00fa\u010dinnosti a bezpe\u010dnosti u\u017e\u00edv\u00e1n\u00ed psychedelik k l\u00e9\u010db\u011b du\u0161evn\u00edch a psychiatrick\u00fdch probl\u00e9m\u016f, jako je posttraumatick\u00e1 stresov\u00e1 porucha, deprese, \u00fazkost a z\u00e1vislost na n\u00e1vykov\u00fdch l\u00e1tk\u00e1ch. <\/p>\n\n\n\n

Pou\u017eit\u00ed psychedelik k l\u00e9\u010db\u011b fyzick\u00e9 bolesti<\/h2>\n\n\n\n

Pokud v\u0161ak jde o pou\u017eit\u00ed psychedelik k l\u00e9\u010db\u011b chronick\u00e9 bolesti, je v\u00fdzkum\u016f zat\u00edm m\u00e9n\u011b. A p\u0159esto\u017ee v\u00fdzkum, kter\u00fd se nyn\u00ed objevuje, je slibn\u00fd, je st\u00e1le ve velmi ran\u00e9 f\u00e1zi. To je v\u0161ak ne poprv\u00e9<\/a> byl navr\u017een v\u00fdzkum u\u017e\u00edv\u00e1n\u00ed psychedelik p\u0159i fyzick\u00e9 bolesti. Vzhledem k tomu, \u017ee se chyst\u00e1 mnoho studi\u00ed, se jist\u011b brzy dozv\u00edme mnohem v\u00edce. <\/p>\n\n\n\n

Existuje tak\u00e9 mnoho lid\u00ed, kte\u0159\u00ed se r\u00e1di pod\u011bl\u00ed o sv\u00e9 p\u0159\u00edb\u011bhy o tom, jak psychedelika l\u00e9\u010dila chronickou bolest nebo jim pomohla se s n\u00ed vyrovnat: <\/strong><\/p>\n\n\n\n

Jedn\u00edm z nich je Jose Martines, veter\u00e1n, o n\u011bm\u017e New York Times psaly v roce 2021. Po zran\u011bn\u00ed podstoupil 19 operac\u00ed a st\u00e1le trp\u011bl extr\u00e9mn\u00edmi bolestmi. Kv\u016fli tomu byl z\u00e1visl\u00fd na opioidech. Vyzkou\u0161el v\u0161ak psilocybin, kter\u00fd mu na\u0161t\u011bst\u00ed zm\u011bnil \u017eivot. Martinez to vysv\u011btlil den\u00edku New York Times; <\/p>\n\n\n\n

\"Psychedelika mi pomohla uv\u011bdomit si, \u017ee moje probl\u00e9my jsou mal\u00e9 ve srovn\u00e1n\u00ed s v\u011bt\u0161\u00edmi probl\u00e9my sv\u011bta, jako je hladomor a rakovina... Te\u010f u\u017e ch\u00e1pu, pro\u010d jsem vlastn\u011b na sv\u011bt\u011b, a to je rozesm\u00edvat lidi a p\u0159ipom\u00ednat jim, \u017ee \u017eivot m\u016f\u017ee b\u00fdt kr\u00e1sn\u00fd, i kdy\u017e to nen\u00ed tak jednoduch\u00e9.\"<\/em><\/p>\n\n\n\n

\"\"
p\u0159es Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

P\u0159esto\u017ee st\u00e1le trp\u00ed ur\u010dit\u00fdmi bolestmi, jeho pohled na v\u011bc se zm\u011bnil. Krom\u011b toho, \u017ee je hlasit\u00fdm zast\u00e1ncem psychedelik a pomohl zalo\u017eit Iniciativu pro v\u00fdzkum psychedelik a zdrav\u00ed na Kalifornsk\u00e9 univerzit\u011b v San Diegu. (PHRI<\/a>)<\/em>, je tak\u00e9 paralympijsk\u00fdm surfa\u0159em a sportovn\u00edm nad\u0161encem. <\/p>\n\n\n\n

Psilocybin na fantomovou bolest kon\u010detin?<\/h2>\n\n\n\n

Dal\u0161\u00edm takov\u00fdm p\u0159\u00edb\u011bhem je p\u0159\u00edb\u011bh Alberta Yu-Mina Lina, v\u011bdce a badatele National Geographic. V roce 2016 p\u0159i\u0161el p\u0159i nehod\u011b v pou\u0161ti o spodn\u00ed \u010d\u00e1st nohy. Nedlouho pot\u00e9 za\u010dal za\u017e\u00edvat stra\u0161liv\u00e9 pot\u00ed\u017ee. fantomov\u00e9 bolesti kon\u010detin<\/a>. Po jednom sezen\u00ed s psilocybinem Lin zjistil, \u017ee se jeho bolest v\u00fdrazn\u011b zm\u00edrnila. \u0158\u00edk\u00e1, \u017ee mu tato zku\u0161enost vr\u00e1tila \u017eivot. <\/p>\n\n\n\n

Historie u\u017e\u00edv\u00e1n\u00ed psychedelik k l\u00e9\u010db\u011b fyzick\u00e9 bolesti<\/h2>\n\n\n\n

Jak jsme ji\u017e zm\u00ednili, v\u00fdzkum vyu\u017eit\u00ed psychedelik k l\u00e9\u010db\u011b fyzick\u00e9 bolesti nen\u00ed nov\u00fd. Prvn\u00ed v\u00fdzkumy se datuj\u00ed do roku 1964, kdy anesteziolog Eric Kast podal 100 mikrogram\u016f LSD 50 pacient\u016fm, kte\u0159\u00ed si ho \"v\u00e1\u017en\u011b nemocn\u00fd\" <\/em>pacient\u016f. Tito pacienti trp\u011bli v\u0161\u00edm mo\u017en\u00fdm od gangr\u00e9ny po rakovinu. Pot\u00e9 porovnal jejich reakci na bolest se dv\u011bma dal\u0161\u00edmi syntetick\u00fdmi opioidy. (Demerol a Dilaudid.) <\/em>Kast zjistil, \u017ee \"Ve srovn\u00e1n\u00ed s LSD-25 byly ob\u011b [ostatn\u00ed] drogy ve sv\u00e9m analgetick\u00e9m \u00fa\u010dinku nedostate\u010dn\u00e9.\" <\/em><\/p>\n\n\n\n

Bohu\u017eel nedlouho pot\u00e9 \"v\u00e1lka proti drog\u00e1m\" a negativn\u00ed obraz potla\u010dily pokusy o studium psychedelik v USA a mnoha dal\u0161\u00edch zem\u00edch. To se na\u0161t\u011bst\u00ed m\u011bn\u00ed. <\/p>\n\n\n\n

Ned\u00e1vn\u00e9 studie ukazuj\u00ed sm\u011br<\/h2>\n\n\n\n

V roce 2020 prob\u011bhne dvojit\u011b zaslepen\u00e1, placebem kontrolovan\u00e1, randomizovan\u00e1 studie. studium<\/a> proveden\u00e1 nizozemskou Maastrichtskou univerzitou byla publikov\u00e1na v \u010dasopise Journal of Psychopharmacology. Zam\u011b\u0159ila se na psychedelika a fyzickou bolest. Kdy\u017e \u00fa\u010dastn\u00edci dostali LSD, a to i v n\u00edzk\u00fdch d\u00e1vk\u00e1ch, dok\u00e1zali udr\u017eet ruce ve vod\u011b t\u00e9m\u011b\u0159 pod bodem mrazu t\u00e9m\u011b\u0159 stejn\u011b dlouho jako ti, kte\u0159\u00ed u\u017e\u00edvali opioidy, jako je morfin. (na z\u00e1klad\u011b \u00fadaj\u016f z p\u0159edchoz\u00edch studi\u00ed.) <\/em>Auto\u0159i dosp\u011bli k z\u00e1v\u011bru, \u017ee v n\u00edzk\u00fdch d\u00e1vk\u00e1ch m\u016f\u017ee LSD \"...p\u0159edstavuj\u00ed novou farmakologickou l\u00e9\u010dbu.\"<\/em><\/p>\n\n\n\n

\"\"
Foto: Scott Graham on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Studie z roku 2021 pak zjistila, \u017ee lid\u00e9 trp\u00edc\u00ed chronickou bolest\u00ed vykazovali b\u011bhem psychedelick\u00fdch z\u00e1\u017eitk\u016f a po nich v\u00fdrazn\u011b lep\u0161\u00ed hodnocen\u00ed bolesti. Dal\u0161\u00ed studie z roku 2021 zjistila, \u017ee p\u0159i pod\u00e1n\u00ed by\u0165 jedin\u00e9 d\u00e1vky psilocybinu osoby trp\u00edc\u00ed migr\u00e9nou hl\u00e1sily pozoruhodn\u00e9 sn\u00ed\u017een\u00ed p\u0159\u00edznak\u016f migr\u00e9ny. To bylo srovn\u00e1v\u00e1no s t\u011bmi, kter\u00fdm bylo pod\u00e1no placebo. <\/p>\n\n\n\n

Krom\u011b toho mnoho dal\u0161\u00edch v\u00fdzkumn\u00edk\u016f oznamuje podobn\u00e9 studie psychedelik k l\u00e9\u010db\u011b fyzick\u00e9 bolesti. <\/p>\n\n\n\n

Kalifornsk\u00e1 univerzita v San Francisku brzy zah\u00e1j\u00ed studii, kter\u00e1 bude zkoumat, zda terapie psilocybinem m\u016f\u017ee l\u00e9\u010dit bolesti doln\u00ed \u010d\u00e1sti zad. V\u011bdci uv\u00e1d\u011bj\u00ed; \"Tato studie zkoum\u00e1 \u00fa\u010dinky jednor\u00e1zov\u00e9 d\u00e1vky psilocybinu v kombinaci s terapeutick\u00fdm p\u0159\u00edpravkem a integra\u010dn\u00edmi studiemi... Douf\u00e1me, \u017ee terapie psilocybinem povede ke zlep\u0161en\u00ed interference bolesti... souvisej\u00edc\u00ed s chronickou bolest\u00ed zad.\"<\/em><\/p>\n\n\n\n

\"\"
Foto: Jonathan Borba on Unsplash<\/em><\/mark><\/figcaption><\/figure>\n\n\n\n

Nal\u00e9hav\u00e1 pot\u0159eba psychedelick\u00e9 alternativy <\/h2>\n\n\n\n

Nal\u00e9havost v\u00fdzkumu psychedelik jako l\u00e9\u010dby chronick\u00e9 bolesti pramen\u00ed z toho, \u017ee v sou\u010dasnosti jsou nej\u010dast\u011bj\u0161\u00ed l\u00e9\u010debnou metodou opioidy. V jedn\u00e9 studii bylo uvedeno, \u017ee l\u00e9ka\u0159i p\u0159edepsali opioidy \u2154 veter\u00e1n\u016f s chronickou bolest\u00ed v pr\u016fb\u011bhu jednoho roku. To je sice v po\u0159\u00e1dku, pokud jsou opioidy u\u017e\u00edv\u00e1ny podle p\u0159edpisu, ale nesou s sebou zna\u010dn\u00e9 riziko z\u00e1vislosti a p\u0159ed\u00e1vkov\u00e1n\u00ed. A kdy\u017e v\u00e1s neust\u00e1le n\u011bco bol\u00ed, je velmi snadn\u00e9 st\u00e1t se z\u00e1visl\u00fdm na l\u00e1tce, kter\u00e1 tlum\u00ed bolest. Podle CDC<\/a>, opioidy jen v roce 2020 p\u0159\u00edmo zp\u016fsobily nebo p\u0159isp\u011bly k 68 630 \u00famrt\u00edm v USA. <\/p>\n\n\n\n

U veter\u00e1n\u016f je dvakr\u00e1t vy\u0161\u0161\u00ed pravd\u011bpodobnost p\u0159ed\u00e1vkov\u00e1n\u00ed drogami ne\u017e u ostatn\u00ed populace a tak\u00e9 mnohem vy\u0161\u0161\u00ed pravd\u011bpodobnost, \u017ee sp\u00e1chaj\u00ed sebevra\u017edu. <\/p>\n\n\n\n

Psychedelika nejsou n\u00e1vykov\u00e1 a \"p\u0159epojuj\u00ed\" mozek<\/h2>\n\n\n\n

Na rozd\u00edl od opioid\u016f nejsou psychedelika n\u00e1vykov\u00e1 a je t\u00e9m\u011b\u0159 nemo\u017en\u00e9 se jimi smrteln\u011b p\u0159ed\u00e1vkovat. V roce 2020 bylo v p\u0159ehledov\u00e9m \u010dl\u00e1nku v publikaci British Medical Journal uvedeno;<\/p>\n\n\n\n

\"Psychedelick\u00e9 l\u00e1tky maj\u00ed obecn\u011b p\u0159\u00edzniv\u00fd bezpe\u010dnostn\u00ed profil, zejm\u00e9na ve srovn\u00e1n\u00ed s opioidn\u00edmi analgetiky.\"<\/em><\/p>\n\n\n\n

Psychedelika nav\u00edc mohou p\u0159in\u00e1\u0161et dlouhodob\u011bj\u0161\u00ed \u00falevu ne\u017e opioidy, kter\u00e9 p\u016fsob\u00ed pouze do doby, ne\u017e vyprchaj\u00ed. A v n\u011bkter\u00fdch p\u0159\u00edpadech, jako je nap\u0159\u00edklad syndrom fantomov\u00fdch kon\u010detin, se jedn\u00e1 o neurologick\u00e9 posti\u017een\u00ed. Potenci\u00e1l psychedelik reorganizovat dr\u00e1hy v mozku.<\/a>, by mohla b\u00fdt kl\u00ed\u010dem k dlouhodob\u011bj\u0161\u00ed l\u00e9\u010db\u011b t\u011bchto stav\u016f. <\/p>\n\n\n\n

\"\"
p\u0159es Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

P\u0159edb\u011b\u017en\u00e1 zji\u0161t\u011bn\u00ed Iniciativy pro v\u00fdzkum psychedelik a zdrav\u00ed na Kalifornsk\u00e9 univerzit\u011b v San Diegu nazna\u010duj\u00ed, \u017ee psychedelika mohou v\u00fdznamn\u011b a mo\u017en\u00e1 trvale sn\u00ed\u017eit chronickou bolest zp\u016fsobenou mnoha r\u016fzn\u00fdmi stavy. Pat\u0159\u00ed mezi n\u011b clusterov\u00e9 bolesti hlavy, fantomov\u00e9 bolesti kon\u010detin, tinnitus a komplexn\u00ed region\u00e1ln\u00ed bolestiv\u00e9 poruchy. <\/p>\n\n\n\n

Za\u010d\u00e1tek revoluce ve zdravotnictv\u00ed?<\/h2>\n\n\n\n

To by mohl b\u00fdt za\u010d\u00e1tek revoluce ve zdravotnictv\u00ed. Chronick\u00e1 bolest je celosv\u011btov\u011b hlavn\u00ed p\u0159\u00ed\u010dinou invalidity. Ti, kte\u0159\u00ed j\u00ed trp\u00ed, by nem\u011bli riskovat z\u00e1vislost a p\u0159ed\u00e1vkov\u00e1n\u00ed jen proto, aby si l\u00e9\u010dili sv\u00e9 p\u0159\u00edznaky . Psychedelika, jako je psilocybin, mohou b\u00fdt kl\u00ed\u010dem k uzdraven\u00ed milion\u016f lid\u00ed po cel\u00e9m sv\u011bt\u011b. <\/p>\n\n\n\n

\"\"<\/figure>","protected":false},"excerpt":{"rendered":"

T\u00e9m\u011b\u0159 50% veter\u00e1n\u016f, kte\u0159\u00ed za\u017eili boj, se vrac\u00ed s chronickou bolest\u00ed. Oproti tomu 26% b\u011b\u017en\u00e9 populace trp\u00ed chronickou bolest\u00ed, tak\u017ee pravd\u011bpodobnost posti\u017een\u00ed veter\u00e1n\u016f je t\u00e9m\u011b\u0159 dvakr\u00e1t vy\u0161\u0161\u00ed. Jeden pr\u016fzkum zjistil, \u017ee p\u0159ibli\u017en\u011b polovina veter\u00e1n\u016f s chronickou bolest\u00ed trp\u011bla nejm\u00e9n\u011b rok. A z nich v\u00edce ne\u017e polovina trp\u011bla bolestmi neust\u00e1le nebo alespo\u0148 denn\u011b. V\u00edce ne\u017e 50% z nich hodnotilo svou chronickou bolest jako silnou nebo st\u0159edn\u011b silnou.<\/p>","protected":false},"author":1,"featured_media":113774,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88],"tags":[],"topics":[],"class_list":["post-113751","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/113751","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/comments?post=113751"}],"version-history":[{"count":1,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/113751\/revisions"}],"predecessor-version":[{"id":122308,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/113751\/revisions\/122308"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media\/113774"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media?parent=113751"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/categories?post=113751"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/tags?post=113751"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/topics?post=113751"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}