{"id":13232,"date":"2020-06-10T12:34:52","date_gmt":"2020-06-10T12:34:52","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=13232"},"modified":"2023-05-11T18:22:49","modified_gmt":"2023-05-11T16:22:49","slug":"study-predicts-trip","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/cs\/blog\/study-predicts-trip\/","title":{"rendered":"Nov\u00e1 studie mozku p\u0159edpov\u00edd\u00e1 dobr\u00fd nebo \u0161patn\u00fd v\u00fdlet"},"content":{"rendered":"<p class=\"has-medium-font-size wp-block-paragraph\"><strong>Tyto poznatky vysv\u011btluj\u00ed, pro\u010d psychedelika pronikaj\u00ed do l\u00e9\u010dby poruch n\u00e1lady, jako jsou nap\u0159. <a href=\"https:\/\/staging.wholecelium.com\/cs\/articles\/psychedelic-studies\/microdosing-magic-truffles-for-depression\/\" target=\"_blank\" rel=\"noreferrer noopener\">deprese<\/a>. Studie d\u00e1le ur\u010dila, kter\u00e9 \u010d\u00e1sti mozku se zapojuj\u00ed b\u011bhem \"dobr\u00e9ho tripu\" a \"\u0161patn\u00e9ho tripu\". To je n\u011bco, co nebylo nikdy p\u0159edt\u00edm provedeno.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-the-study\"><em>Studie<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Studie byla kontrolov\u00e1na placebem a z\u00fa\u010dastnilo se j\u00ed 60 zdrav\u00fdch dobrovoln\u00edk\u016f. Po pod\u00e1n\u00ed psilocybinu nebo placeba byl mozek dobrovoln\u00edk\u016f sledov\u00e1n pomoc\u00ed p\u0159\u00edstroje MRI. V\u00fdzkumn\u00edci sledovali reakce glutam\u00e1tu na psilocybin. <a rel=\"noreferrer noopener\" href=\"https:\/\/neurohacker.com\/what-is-glutamate\" target=\"_blank\">Glutam\u00e1t<\/a> je nejb\u011b\u017en\u011bj\u0161\u00edm neurotransmiterem v mozku a centr\u00e1ln\u00ed nervov\u00e9 soustav\u011b. Pod\u00edl\u00ed se na t\u00e9m\u011b\u0159 v\u0161ech excita\u010dn\u00edch funkc\u00edch mozku a je hlavn\u00edm zprost\u0159edkovatelem smyslov\u00fdch informac\u00ed, emoc\u00ed, pozn\u00e1v\u00e1n\u00ed a motorick\u00e9 koordinace. Ji\u017e dlouho se nazna\u010duje souvislost mezi n\u00edm <em>(glutam\u00e1t)<\/em> a poruchy sebepro\u017e\u00edv\u00e1n\u00ed, jako je \u00fazkost nebo schizofrenie.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-finding-no-1\"><em>Zji\u0161t\u011bn\u00ed \u010d. 1<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">P\u0159i studiu aktivity v prefront\u00e1ln\u00ed k\u016f\u0159e a hipokampu.<em> (dv\u011b oblasti mozku prim\u00e1rn\u011b spojen\u00e9 s egem)<\/em> po pod\u00e1n\u00ed psilocybinu v\u011bdci zjistili z\u0159eteln\u00e9 zv\u00fd\u0161en\u00ed aktivity glutam\u00e1tu. Ji\u017e d\u0159\u00edve byla vyslovena hypot\u00e9za, \u017ee p\u0159i tripu s psychedelick\u00fdmi drogami doch\u00e1z\u00ed k aktivaci glutam\u00e1tu. Poprv\u00e9 v\u0161ak byl tento d\u016fkaz nalezen ve studii na lidech. To ukazuje, \u017ee existuje neurologick\u00fd z\u00e1klad pro l\u00e9\u010debn\u00e9 \u00fa\u010dinky psilocybinu, kter\u00e9 v sou\u010dasn\u00e9 dob\u011b vytv\u00e1\u0159ej\u00ed titulky novin.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-finding-no-2\"><em>Zji\u0161t\u011bn\u00ed \u010d. 2<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Druh\u00e9 zji\u0161t\u011bn\u00ed v\u0161ak bylo pro v\u00fdzkumn\u00edky p\u0159ekvapen\u00edm. Pomoc\u00ed vy\u0161et\u0159en\u00ed magnetickou rezonanc\u00ed zjistili, \u017ee zat\u00edmco hladina glutam\u00e1tu v prefront\u00e1ln\u00ed k\u016f\u0159e se po pod\u00e1n\u00ed psilocybinu zv\u00fd\u0161ila, v hipokampu se sn\u00ed\u017eila. Prost\u0159ednictv\u00edm vlastn\u00edho pocitu ega, kter\u00fd dobrovoln\u00edci uv\u00e1d\u011bli, v\u011bdci objevili souvislost mezi oblast\u00ed mozku aktivovanou glutam\u00e1tem a t\u00edm, zda byl trip pops\u00e1n jako \"dobr\u00fd\" nebo \"\u0161patn\u00fd\" z hlediska rozpu\u0161t\u011bn\u00ed ega.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-good-trip\"><em>Dobr\u00fd v\u00fdlet<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Pozitivn\u00ed rozpu\u0161t\u011bn\u00ed ega <em>(aneb \"\u0161\u0165astnou cestu\" v\u00e1m i mn\u011b)<\/em> se \u0159ad\u00ed do kategorie euforie a dobr\u00e9 n\u00e1lady, pocitu soun\u00e1le\u017eitosti se sv\u011btem. Tento \"dobr\u00fd v\u00fdlet\" byl pro\u017e\u00edv\u00e1n p\u0159edev\u0161\u00edm p\u0159i ni\u017e\u0161\u00ed hladin\u011b glutam\u00e1tu v hipokampu. Hipokampus je spojen s \u00farovn\u00ed na\u0161eho sebev\u011bdom\u00ed. Sn\u00ed\u017een\u00ed aktivity zde by mohlo vysv\u011btlit \u00fa\u010dinnost psilocybinu ve studi\u00edch poruch n\u00e1lady. Do\u010dasn\u00e1 depersonalizace zp\u016fsoben\u00e1 tripem d\u00e1v\u00e1 subjektu mo\u017enost resetovat se a distancovat se od p\u0159edchoz\u00edch negativn\u00edch n\u00e1vyk\u016f a emo\u010dn\u00edch stav\u016f.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-bad-trip\"><em>\u0160patn\u00fd v\u00fdlet<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Negativn\u00ed rozpu\u0161t\u011bn\u00ed ega <em>(tj. \"\u0161patn\u00fd v\u00fdlet\") <\/em>se vyskytovaly p\u0159i vy\u0161\u0161\u00edch hladin\u00e1ch glutam\u00e1tu v prefront\u00e1ln\u00ed k\u016f\u0159e. To bylo pops\u00e1no jako ztr\u00e1ta rozhodovac\u00edch schopnost\u00ed, samostatnosti, z\u00e1m\u011br\u016f a spont\u00e1nn\u00edch pohyb\u016f. To d\u00e1v\u00e1 smysl, proto\u017ee prefront\u00e1ln\u00ed k\u016fra je zn\u00e1m\u00e1 rozhodov\u00e1n\u00edm, zprost\u0159edkov\u00e1n\u00edm soci\u00e1ln\u00edho chov\u00e1n\u00ed, projevem osobnosti a formulov\u00e1n\u00edm komplexn\u00edho chov\u00e1n\u00ed.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-making-predictions\"><em>Vytv\u00e1\u0159en\u00ed p\u0159edpov\u011bd\u00ed<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Nicm\u00e9n\u011b vy\u0161et\u0159en\u00ed magnetickou rezonanc\u00ed tak\u00e9 uk\u00e1zalo, \u017ee dobrovoln\u00edci, kte\u0159\u00ed m\u011bli psilocybin, za\u017eili b\u011bhem sv\u00e9ho tripu jak \"dobr\u00e9\", tak \"\u0161patn\u00e9\" z\u00e1\u017eitky. To bylo zp\u016fsobeno t\u00edm, \u017ee se v pr\u016fb\u011bhu m\u011bnila hladina glutam\u00e1tu v mozkov\u00fdch oblastech. To odr\u00e1\u017e\u00ed zku\u0161enost psychedelick\u00fdch badatel\u016f, \u017ee trip zahrnuj\u00edc\u00ed rozpu\u0161t\u011bn\u00ed ega nebo \"smrt\" m\u016f\u017ee b\u00fdt sou\u010dasn\u011b n\u00e1dhern\u00fd i d\u011bsiv\u00fd. V\u017edy je v\u0161ak pom\u011brn\u011b hlubok\u00fd. Vzru\u0161uj\u00edc\u00ed je, \u017ee tato zji\u0161t\u011bn\u00ed byla natolik v\u00fdznamn\u00e1, \u017ee v\u011bdci dok\u00e1zali pouze na z\u00e1klad\u011b sn\u00edmk\u016f mozku z magnetick\u00e9 rezonance p\u0159edpov\u011bd\u011bt, zda dobrovoln\u00edci pro\u017eili p\u0159ev\u00e1\u017en\u011b dobr\u00fd nebo \u0161patn\u00fd trip.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-learning-more-one-psychedelic-study-at-a-time\"><em>V\u00edce informac\u00ed, jedna psychedelick\u00e1 studie za druhou...<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><br>A\u010dkoli to st\u00e1le nen\u00ed zcela zn\u00e1mo <em>pro\u010d <\/em>tyto poznatky, op\u011bt zji\u0161\u0165ujeme, \u017ee studium psychedelik n\u00e1s st\u00e1le v\u00edce p\u0159ibli\u017euje k pochopen\u00ed p\u016fvodu a fungov\u00e1n\u00ed ega. Odtud se m\u016f\u017eeme dozv\u011bd\u011bt o vzniku \"j\u00e1\" a mo\u017en\u00e1 jednoho dne i o genezi samotn\u00e9ho v\u011bdom\u00ed. Krom\u011b medic\u00ednsk\u00fdch a terapeutick\u00fdch p\u0159\u00ednos\u016f studium psychedelik st\u00e1le zvy\u0161uje na\u0161e porozum\u011bn\u00ed lidsk\u00e9mu stavu.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">P\u0159e\u010dt\u011bte si celou studii, kterou zve\u0159ejnil <em>Neuropsychofarmakologie<\/em><a href=\"https:\/\/www.nature.com\/articles\/s41386-020-0718-8#Sec8\" target=\"_blank\" rel=\"noreferrer noopener\"><em> <\/em>zde<\/a>. <\/p>","protected":false},"excerpt":{"rendered":"<p>Na Maastrichtsk\u00e9 univerzit\u011b v Nizozemsku prob\u011bhla pr\u016flomov\u00e1 studie, prvn\u00ed sv\u00e9ho druhu proveden\u00e1 na lidech. Tato studie osv\u011btluje, jak psilocybin ovliv\u0148uje neurologick\u00e9 mechanismy a vyvol\u00e1v\u00e1 pocit rozpu\u0161t\u011bn\u00ed ega neboli \"smrti ega\". <\/p>","protected":false},"author":1,"featured_media":13300,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-13232","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/13232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/comments?post=13232"}],"version-history":[{"count":1,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/13232\/revisions"}],"predecessor-version":[{"id":123893,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/13232\/revisions\/123893"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media\/13300"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media?parent=13232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/categories?post=13232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/tags?post=13232"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/topics?post=13232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}