<\/p>\n\n\n\n
Nov\u00fd v\u00fdzkum uk\u00e1zal, \u017ee v magick\u00fdch houb\u00e1ch je mnohem v\u00edce \u00fa\u010dinn\u00fdch l\u00e1tek ne\u017e jen psilocybin. Nav\u00edc je velmi pravd\u011bpodobn\u00e9, \u017ee hraj\u00ed z\u00e1sadn\u00ed roli v psychedelick\u00fdch \u00fa\u010dinc\u00edch hub. Jedn\u00e1 se o tzv. doprovodn\u00fd efekt. Je v\u0161eobecn\u011b zn\u00e1mo, \u017ee existuje s konop\u00ed<\/a>. D\u0159\u00edv\u011bj\u0161\u00ed v\u00fdzkum vlastnost\u00ed konop\u00ed se zam\u011b\u0159oval pouze na THC. Brzy v\u0161ak studie zjistily, \u017ee se jedn\u00e1 o celou soustavu slou\u010denin, kter\u00e9 spole\u010dn\u011b vytv\u00e1\u0159ej\u00ed jeho \u00fa\u010dinek. Nyn\u00ed se shoduj\u00ed na tom, \u017ee CBD je vedle dal\u0161\u00edch slou\u010denin z\u00e1sadn\u00ed pro to, aby konop\u00ed dos\u00e1hlo sv\u00e9ho pln\u00e9ho potenci\u00e1lu. Zaj\u00edmav\u00e9 je, \u017ee v p\u0159\u00edpad\u011b magick\u00fdch hub to teprve objevujeme. Zd\u00e1 se, \u017ee psychoaktivn\u00ed slou\u010deniny se r\u00e1dy dr\u017e\u00ed v part\u011b. <\/p>\n\n\n\n Tak\u017ee, psilocybin<\/a> je slou\u010denina, kter\u00e1 obvykle p\u0159itahuje nejv\u011bt\u0161\u00ed pozornost. Magick\u00e9 houby obsahuj\u00ed v z\u00e1vislosti na druhu 0,2-1,8% psilocybinu v su\u0161in\u011b. Po konzumaci se psilocybin rychle p\u0159em\u011b\u0148uje na sv\u016fj aktivn\u00ed metabolit, psilocin. Psilocybin i psilocin se v\u00e1\u017eou na serotoninov\u00e9 receptory. Tato dvoj\u010data pot\u00ed\u017eist\u016f jsou tedy zodpov\u011bdn\u00e1 za v\u011bt\u0161inu psychedelick\u00fdch \u00fa\u010dink\u016f magick\u00fdch hub.<\/p>\n\n\n\n Psilocyin tvo\u0159\u00ed v z\u00e1vislosti na druhu asi 0,02-0,6% su\u0161iny magick\u00fdch hub. Dal\u0161\u00ed nejhojn\u011bji zastoupenou molekulou je pak je\u0161t\u011b m\u00e9n\u011b zn\u00e1m\u00fd baeocystin - v sou\u010dasn\u00e9 dob\u011b mu v\u0161ak p\u0159\u00edli\u0161 nerozum\u00edme. Stejn\u011b jako psilocin je to dal\u0161\u00ed deriv\u00e1t psilocybinu, tak\u017ee je pravd\u011bpodobn\u00e9, \u017ee m\u00e1 tak\u00e9 n\u011bjak\u00fd psychoaktivn\u00ed v\u00fdsledek. V\u011bdec Jochen Gartz popsal, \u017ee mal\u00e1 d\u00e1vka 4 mg mu poskytla \"jemn\u00fd halucinogenn\u00ed z\u00e1\u017eitek\".<\/em> <\/em>Baeocystin je v su\u0161en\u00fdch magick\u00fdch houb\u00e1ch p\u0159\u00edtomen v mno\u017estv\u00ed p\u0159ibli\u017en\u011b 0,005-0,36% v z\u00e1vislosti na druhu.<\/p>\n\n\n\n P\u0159\u00edtomnost beta-karbolin\u016f byla ned\u00e1vno objevena tak\u00e9 v magick\u00fdch houb\u00e1ch. Beta-karboliny jsou skupinou alkaloid\u016f, kter\u00e9 se vyskytuj\u00ed v mnoha druz\u00edch rostlin. P\u0159edev\u0161\u00edm v l\u00e9\u010div\u00fdch rostlin\u00e1ch ayahuasca<\/a> zahrnuje beta-karboliny harmin, harmalin<\/em>a tetrahydroharm\u00edn<\/em>. Ty br\u00e1n\u00ed enzymu monoaminooxid\u00e1ze (MAO), kter\u00fd se nach\u00e1z\u00ed v na\u0161em \u017ealudku. Ajahuaskov\u00e9 n\u00e1levy obsahuj\u00ed psychedelickou molekulu DMT<\/a>, kter\u00fd je obvykle rozkl\u00e1d\u00e1n enzymem MAO. Nyn\u00ed vid\u00edte, jak do hry vstupuj\u00ed beta-karboliny; blokuj\u00ed MAO a pom\u00e1haj\u00ed DMT p\u0159e\u017e\u00edt d\u00e9le v t\u011ble, kde m\u016f\u017ee m\u00edt psychoaktivn\u00ed dopad.<\/p>\n\n\n\n Ned\u00e1vno byly beta-karboliny harmane, harmine, norharmane<\/em> a perlolyrin<\/em> byly nalezeny u \u010dty\u0159 druh\u016f hub. Stejn\u011b jako DMT v ayahuasce je i psilocin v t\u011ble rozkl\u00e1d\u00e1n enzymem MAO. Nyn\u00ed v\u0161ak v\u00edme o existenci beta-karbolin\u016f v magick\u00fdch houb\u00e1ch, z \u010deho\u017e m\u016f\u017eeme usuzovat, \u017ee blokuj\u00ed enzym MAO! T\u00edm se z\u00e1\u017eitek z psilocybinu\/psilocinu prodlu\u017euje a zesiluje, proto\u017ee se br\u00e1n\u00ed jeho odbour\u00e1v\u00e1n\u00ed. <\/p>\n\n\n\n Fascinuj\u00edc\u00ed je, \u017ee zji\u0161t\u011bn\u00ed, \u017ee magick\u00e9 houby obsahuj\u00ed tak\u00e9 beta-karboliny, by mohlo znamenat, \u017ee ayahuasca a magick\u00e9 houby jsou srovnateln\u011bj\u0161\u00ed, ne\u017e jsme si mysleli! Je v\u0161ak v magick\u00fdch houb\u00e1ch dostatek beta-karbolin\u016f na to, aby m\u011bly v\u00fdznamn\u00fd vliv na pro\u017eitek u\u017eivatele? Nu\u017ee, nejhojn\u011bji zastoupen\u00fdm z beta-karbolin\u016f nalezen\u00fdch v druz\u00edch magick\u00fdch hub byl nap\u0159. harmane<\/em>, kter\u00e1 se pohybovala v rozmez\u00ed 0,2-21 ug\/g su\u0161en\u00e9 hmoty. V n\u00e1levech ayahuasky jsou beta-karboliny aktivn\u00ed v mno\u017estv\u00edch pouh\u00fdch 0,5 mikrogram\u016f pro pr\u016fm\u011brn\u00e9ho \u010dlov\u011bka. To nazna\u010duje, \u017ee m\u00edrn\u00e1 d\u00e1vka magick\u00e9 houby. (asi 2 gramy su\u0161en\u00fdch hub)<\/em> by bylo dostate\u010dn\u00e9, aby tyto beta-karboliny p\u0159isp\u011bly k cest\u011b.<\/p>\n\n\n\n Vzhledem k tomu, \u017ee v\u011bt\u0161ina klinick\u00fdch v\u00fdzkum\u016f magick\u00fdch hub se soust\u0159edila v\u00fdhradn\u011b na psilocybin, nen\u00ed k dispozici mnoho informac\u00ed, kter\u00e9 by srovn\u00e1valy subjektivn\u00ed v\u00fdsledky psilocybinu s cel\u00fdmi houbami. Nicm\u00e9n\u011b existuj\u00ed dv\u011b studie na zv\u00ed\u0159atech s relevantn\u00edmi v\u00fdsledky. Ve studii z roku 2009 byl my\u0161\u00edm pod\u00e1v\u00e1n bu\u010f \u010dist\u00fd psilocybin, nebo extrakt z magick\u00fdch hub. V\u00fdsledky uk\u00e1zaly, \u017ee extrakt z magick\u00fdch hub byl \u00fa\u010dinn\u011bj\u0161\u00ed p\u0159i sni\u017eov\u00e1n\u00ed nervov\u00e9ho chov\u00e1n\u00ed my\u0161\u00ed ne\u017e samotn\u00fd \u010dist\u00fd psilocybin. <\/p>\n\n\n\n Jin\u00e1 studie z roku 2015 zjistila, \u017ee extrakt z magick\u00e9 houby byl asi desetkr\u00e1t \u00fa\u010dinn\u011bj\u0161\u00ed p\u0159i zm\u011bn\u011b \u00fazkostn\u00e9ho chov\u00e1n\u00ed u my\u0161\u00ed ve srovn\u00e1n\u00ed s \u010dist\u00fdm psilocinem. Zd\u00e1 se, \u017ee se tak potvrzuje to, co v\u011bdci p\u0159edpokl\u00e1dali, kdy\u017e v druz\u00edch magick\u00fdch hub objevili beta-karboliny - \u017ee kl\u00ed\u010dem k jejich \u00fa\u010dinnosti m\u016f\u017ee b\u00fdt doprovodn\u00fd efekt v magick\u00fdch houb\u00e1ch. V podstat\u011b, jak v\u00e1s u\u010dili ve \u0161kole, t\u00fdmov\u00e1 pr\u00e1ce obvykle p\u0159in\u00e1\u0161\u00ed lep\u0161\u00ed v\u00fdsledky.<\/p>\n\n\n\n Nav\u00edc bylo ned\u00e1vno zji\u0161t\u011bno, \u017ee r\u016fzn\u00e9 \u010d\u00e1sti t\u00e9\u017ee houby mohou obsahovat r\u016fzn\u00e1 mno\u017estv\u00ed psychoaktivn\u00edch l\u00e1tek. U n\u011bkter\u00fdch druh\u016f mohou klobou\u010dky obsahovat dvakr\u00e1t v\u00edce psilocybinu ne\u017e stonky! Podobn\u011b magick\u00e9 lan\u00fd\u017ee obsahuj\u00ed r\u016fzn\u00e1 mno\u017estv\u00ed psilocybinu ve srovn\u00e1n\u00ed s magick\u00fdmi houbami. <\/p>\n\n\n\n Co to tedy znamen\u00e1 pro na\u0161e ch\u00e1p\u00e1n\u00ed z\u00e1\u017eitku z kouzeln\u00fdch hub? Obecn\u011b plat\u00ed, \u017ee t\u00e9m\u011b\u0159 v\u0161echny l\u00e9ka\u0159sk\u00e9 v\u00fdzkumy l\u00e9\u010debn\u00e9ho potenci\u00e1lu magick\u00fdch hub na lidech vyu\u017e\u00edvaly sp\u00ed\u0161e izolovan\u00fd psilocybin nebo psilocin ne\u017e extrakt z cel\u00e9 houby..<\/strong><\/p>\n\n\n\n Tento nov\u00fd z\u00e1jem o efekt doprovodu v\u0161ak pravd\u011bpodobn\u011b poroste. Mo\u017en\u00e1, \u017ee v budoucnosti, kdy bude psychedelick\u00e1 l\u00e9\u010dba b\u011b\u017en\u00e1, bude rozd\u00edl mezi t\u00edm, zda si spot\u0159ebitel\u00e9 vyberou dopln\u011bk stravy s izolovan\u00fdm psilocybinem od farmaceutick\u00e9 spole\u010dnosti, nebo mikrod\u00e1vku skute\u010dn\u00e9 houby \u010di lan\u00fd\u017ee, spo\u010d\u00edvat v aspektech, jako je entourage efekt. To je d\u016fvod, pro\u010d je entourage efekt d\u016fle\u017eit\u00fd. <\/p>\n\n\n\n P\u0159i \u010dten\u00ed v\u00fdzkumn\u00e9 studie o syntetick\u00e9m psilocybinu nebo psilocinu je tedy dobr\u00e9 m\u00edt tento rozd\u00edl na pam\u011bti. A a\u017e budete p\u0159\u00ed\u0161t\u011b tripovat na houb\u00e1ch nebo lan\u00fd\u017e\u00edch, nezapome\u0148te ocenit harmonii slou\u010denin, kter\u00e9 spole\u010dn\u011b vytv\u00e1\u0159ej\u00ed v\u00e1\u0161 z\u00e1\u017eitek!<\/p>","protected":false},"excerpt":{"rendered":" Pokud jde o magick\u00e9 houby a v\u00fdzkum jejich vyu\u017eit\u00ed, je to pr\u00e1v\u011b \u010d\u00e1stice psilocybinu, kter\u00e1 je \u010dasto v centru pozornosti. Psilocybin je nejroz\u0161\u00ed\u0159en\u011bj\u0161\u00ed psychedelickou slo\u017ekou v houb\u00e1ch a magick\u00fdch lan\u00fd\u017e\u00edch. V sou\u010dasn\u00e9 dob\u011b se p\u0159i v\u00fdzkumu prosp\u011b\u0161nosti magick\u00fdch hub \u010dasto vyu\u017e\u00edv\u00e1 pouze tato slou\u010denina, nikoli cel\u00e1 houba. Pro\u010d je tedy lep\u0161\u00ed cel\u00e1 houba? Je \u010das dozv\u011bd\u011bt se, pro\u010d je d\u016fle\u017eit\u00fd entourage efekt.<\/p>","protected":false},"author":1,"featured_media":13913,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-13908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/13908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/comments?post=13908"}],"version-history":[{"count":1,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/13908\/revisions"}],"predecessor-version":[{"id":123871,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/13908\/revisions\/123871"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media\/13913"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media?parent=13908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/categories?post=13908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/tags?post=13908"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/topics?post=13908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Dvoj\u010data Troublemakers<\/em><\/h2>\n\n\n\n
Nepodce\u0148ujte Baeocystin!<\/em><\/h2>\n\n\n\n
Vstupte do Beta-karbolini\u00ed!<\/em><\/h2>\n\n\n\n
Houby a ayahuasca - podobn\u011bj\u0161\u00ed, ne\u017e jsme si mysleli! <\/em><\/h2>\n\n\n\n
Dv\u011b studie vynikaj\u00ed<\/em><\/h2>\n\n\n\n
Siln\u00e9 str\u00e1nky se mohou li\u0161it<\/em><\/h2>\n\n\n\n
Co to znamen\u00e1?<\/em><\/h2>\n\n\n\n
Pro\u010d je efekt Entourage d\u016fle\u017eit\u00fd<\/em><\/h2>\n\n\n\n
Skute\u010dn\u00fd vs. syntetick\u00fd<\/em><\/h2>\n\n\n\n