{"id":14862,"date":"2020-10-17T16:58:00","date_gmt":"2020-10-17T16:58:00","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=14862"},"modified":"2023-05-11T14:16:00","modified_gmt":"2023-05-11T12:16:00","slug":"the-psilocybin-strips-changing-medicine","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/cs\/blog\/the-psilocybin-strips-changing-medicine\/","title":{"rendered":"Psilocybinov\u00e9 prou\u017eky m\u011bn\u00edc\u00ed medic\u00ednu"},"content":{"rendered":"<h2 class=\"wp-block-heading\" id=\"h-the-psilocybin-strips-changing-medicine\"><em>Psilocybinov\u00e9 prou\u017eky m\u011bn\u00edc\u00ed medic\u00ednu<\/em><\/h2>\n\n\n\n\n\n<p class=\"wp-block-paragraph\">V posledn\u00ed dob\u011b se tak\u00e9 mno\u017e\u00ed velk\u00e9 a uzn\u00e1van\u00e9 univerzity, kter\u00e9 zakl\u00e1daj\u00ed vlastn\u00ed centra pro v\u00fdzkum psychedelik, konkr\u00e9tn\u011b minul\u00fd m\u011bs\u00edc Centrum pro v\u011bdu o psychedelik\u00e1ch na Kalifornsk\u00e9 univerzit\u011b v Berkeley.<strong>,<\/strong> Johns Hopkins 2019 a NYU Langone Health. <a aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\" href=\"https:\/\/cheddar.com\/media\/mindmed-psychedelics-nyu-langone-nasdaq-uplist\" target=\"_blank\" rel=\"noreferrer noopener\">nadch\u00e1zej\u00edc\u00ed divize<\/a>, v\u0161ichni hledaj\u00ed dal\u0161\u00ed velk\u00fd objev psychedelick\u00e9 medic\u00edny.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vzru\u0161uj\u00edc\u00ed zpr\u00e1va, \u017ee? Po\u010dkejte, a\u017e se dozv\u00edte o <a label=\"undefined (opens in a new tab)\" href=\"https:\/\/www.cybin.com\/cybin-corp-and-intelgenx-corp-enter-into-feasibility-agreement-for-fast-acting-orally-dissolving-psilocybin-film\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\"><em>Cybin's <\/em>nov\u00fd drti\u010d<\/a>: filmov\u00fd p\u00e1sek s vysokou d\u00e1vkou psilocybinu, kter\u00fd se doslova rozpl\u00fdv\u00e1 v \u00fastech... Jedn\u00e1 se o psilocybinov\u00e9 prou\u017eky, kter\u00e9 m\u011bn\u00ed l\u00e9ky...<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-oral-vs-sublingual-intake-of-psilocybin\"><strong> <\/strong><em>Peror\u00e1ln\u00ed vs. sublingv\u00e1ln\u00ed p\u0159\u00edjem psilocybinu <\/em><\/h2>\n\n\n\n<figure><img decoding=\"async\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/2020\/10\/mouths-scaled-1.jpg\" alt=\"\" \/><figcaption><mark><em>(Foto s laskav\u00fdm svolen\u00edm: webov\u00e9 str\u00e1nky IntelGenX)<\/em><\/mark><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Spole\u010dnost Cybin Corporation spolupracuje s <a aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\" href=\"https:\/\/www.intelgenx.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">IntelGenx<\/a> <strong>,<\/strong> spole\u010dnost zab\u00fdvaj\u00edc\u00ed se technologiemi pro peror\u00e1ln\u00ed pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f, aby <em>Psilotonin\u2122<\/em> - v\u016fbec prvn\u00ed rychle rozpustn\u00e9 prou\u017eky s psilocybinem farmaceutick\u00e9 kvality. 25mg filmov\u00e9 prou\u017eky s psilocybinem jsou ur\u010deny k sublingv\u00e1ln\u00edmu pou\u017eit\u00ed. <em>(nebo \"pod jazyk\")<\/em> na rozd\u00edl od v\u011bt\u0161iny klinick\u00fdch studi\u00ed a psychedelick\u00fdch terapi\u00ed, kter\u00e9 pou\u017e\u00edvaj\u00ed kapsle.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">P\u0159i standardn\u00edm zp\u016fsobu pod\u00e1n\u00ed mus\u00ed psilocybin proj\u00edt tr\u00e1vic\u00edm syst\u00e9mem, aby se mohl p\u0159em\u011bnit na psilocin - bioaktivn\u00ed slou\u010deninu, kter\u00e1 p\u016fsob\u00ed na mozkov\u00e9 bu\u0148ky. <em><a aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\" href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\">\"hormon \u0161t\u011bst\u00ed\"<\/a><\/em><strong><a aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\" href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\"> <\/a><\/strong> receptory.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>(Pozn\u00e1mka na okraj: Proto obvykle trv\u00e1 nejm\u00e9n\u011b 30 minut, ne\u017e se cesta uskute\u010dn\u00ed. Te\u010f u\u017e to v\u00edte!)<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Stoj\u00ed tak\u00e9 za zm\u00ednku, \u017ee 50-60% z d\u00e1vky 25 mg se p\u0159i peror\u00e1ln\u00edm pod\u00e1n\u00ed ztrat\u00ed, co\u017e znamen\u00e1, \u017ee se nikdy nedostane do krevn\u00edho ob\u011bhu... nebo se nedostane do mozku.  Je to proto, \u017ee velk\u00e1 \u010d\u00e1st psilocinu je nejprve metabolizov\u00e1na v j\u00e1trech - nikoli v \u00fastech nebo \u017ealudku.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Na druhou stranu, kdy\u017e se psilocybinov\u00fd filmov\u00fd prou\u017eek rozpust\u00ed pod jazykem, m\u016f\u017ee p\u0159esko\u010dit obvyklou cestu, po kter\u00e9 je \"biologicky dostupn\u00fd\". <em>(nebo se vst\u0159eb\u00e1vaj\u00ed a vyu\u017e\u00edvaj\u00ed v t\u011ble),<\/em> do krevn\u00edho ob\u011bhu.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jukka Karjalainen, vedouc\u00ed l\u00e9ka\u0159 spole\u010dnosti Cybin, \u0159ekl:<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><p> <em>\"P\u0159i d\u00e1vkov\u00e1n\u00ed peror\u00e1ln\u00edm filmem se biologick\u00e1 dostupnost zvy\u0161uje na 100%. D\u00e1vka, kter\u00e1 je pod\u00e1v\u00e1na, je d\u00e1vkou dostupnou pro klinick\u00fd \u00fa\u010dinek.\" <\/em><\/p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-is-your-gut-required-for-psilocybin-s-full-effect\"> <em>Je pro pln\u00fd \u00fa\u010dinek psilocybinu nutn\u00e9 va\u0161e st\u0159evo? <\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Po\u010dkejte. Pokud je d\u00e1vka pod\u00e1van\u00e1 prost\u0159ednictv\u00edm peror\u00e1ln\u011b rozpustn\u00e9ho filmu jen zlomkem d\u00e1vky pot\u0159ebn\u00e9 pro kapsle, jakou roli pak je\u0161t\u011b hraj\u00ed st\u0159eva, pokud jde o psilocybin? Dr. Alan Davis, odborn\u00fd asistent odd\u011blen\u00ed psychedelick\u00e9ho v\u00fdzkumu Univerzity Johnse Hopkinse, nab\u00edz\u00ed ur\u010dit\u00fd n\u00e1hled:<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><p> <em>\"Existuje tak\u00e9 ur\u010dit\u00e1 pochybnost o v\u00fdznamu st\u0159ev p\u0159i naru\u0161ov\u00e1n\u00ed proces\u016f du\u0161evn\u00edho zdrav\u00ed.\"<\/em><\/p><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Davis tak\u00e9 uvedl, \u017ee st\u0159evn\u00ed mikrobiom - tedy souhrn bakteri\u00ed, prvok\u016f a hub, kter\u00e9 se ve v\u00e1s nach\u00e1zej\u00ed - m\u016f\u017ee hr\u00e1t roli v du\u0161evn\u00edm zdrav\u00ed. To je do zna\u010dn\u00e9 m\u00edry zp\u016fsobeno mno\u017estv\u00edm serotoninov\u00fdch p\u0159ena\u0161e\u010d\u016f. <em>(kter\u00fd p\u0159iv\u00e1d\u00ed psilocin do mozku)<\/em> uvnit\u0159 st\u0159eva.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-this-could-mean-for-patients\"><em>Co to m\u016f\u017ee znamenat pro pacienty<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tenk\u00e9 desti\u010dky IntelGenX <a aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\" href=\"https:\/\/www.intelgenx.com\/technology\/versafilm.html\" target=\"_blank\" rel=\"noreferrer noopener\">Technologie VersaFilm<\/a> - kter\u00fd umo\u017e\u0148uje rychl\u00fd rozpad bez nutnosti pou\u017eit\u00ed vody - m\u00e1 mnoho d\u016fsledk\u016f nejen pro psychedelika, ale pro medic\u00ednu obecn\u011b.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">V\u0161estrann\u00e1 platforma pro pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f, jako jsou filmov\u00e9 prou\u017eky, by mohla pacient\u016fm poskytnout \u0159adu dal\u0161\u00edch potenci\u00e1ln\u00edch v\u00fdhod, jako nap\u0159.:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Rychlej\u0161\u00ed buk\u00e1ln\u00ed absorpce<\/strong> <em>(co\u017e znamen\u00e1, \u017ee se l\u00e9k um\u00edst\u00ed mezi d\u00e1sn\u011b a tv\u00e1\u0159.)<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Rychlej\u0161\u00ed sublingv\u00e1ln\u00ed absorpce<\/strong> <em>(\"pod jazykem<\/em>.&#8221;<em>)<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Rychlej\u0161\u00ed n\u00e1stup \u00fa\u010dinku + zv\u00fd\u0161en\u00e1 biologick\u00e1 dostupnost<\/strong>.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>V\u011bt\u0161\u00ed pohodl\u00ed pro pacienty<\/strong> d\u00edky sv\u00e9 mal\u00e9 a tenk\u00e9 velikosti.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tak\u00e9 t\u00edm, \u017ee p\u0159esko\u010d\u00ed metabolismus prvn\u00edho pr\u016fchodu, <em>\"co si d\u00e1vkujete, to dostanete\"<\/em> - tak\u017ee je zde <strong>v\u00edce l\u00e9k\u016f, kter\u00e9 se vst\u0159ebaj\u00ed do krevn\u00edho ob\u011bhu<\/strong> <em>(na rozd\u00edl od kapsl\u00ed)<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Filmov\u00e9 prou\u017eky jsou tak\u00e9 ide\u00e1ln\u00ed pro pacienty, kte\u0159\u00ed maj\u00ed probl\u00e9my s polyk\u00e1n\u00edm, boj\u00ed se, \u017ee se udus\u00ed, nebo je tr\u00e1p\u00ed nevolnost.<strong> chemoterapie<\/strong> nebo <strong>radioterapie<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Je zde tak\u00e9 mo\u017enost neomezen\u00e9ho v\u00fdb\u011bru chut\u00ed, proto\u017ee ve\u0161ker\u00fd p\u0159\u00edjem se odehr\u00e1v\u00e1 v chu\u0165ov\u00fdch poh\u00e1rc\u00edch. <em>(Filmov\u00e9 prou\u017eky s p\u0159\u00edchut\u00ed m\u00e1tov\u00e9 \u010dokol\u00e1dy? Cybin by byl bl\u00e1zen, kdyby neexperimentoval)<\/em>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials-in-jamaica\"><em>Klinick\u00e9 studie na Jamajce<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Spole\u010dnost Cybin hodl\u00e1 prov\u00e1d\u011bt sv\u00e9 zkou\u0161ky na Jamajce, jednom ze \u0161\u0165astn\u00fdch m\u00edst, kde je psilocybin leg\u00e1ln\u00ed, a to celkem ve dvou f\u00e1z\u00edch: F\u00e1ze2A a F\u00e1ze2B. F\u00e1ze 2A by m\u011bla p\u0159esn\u011b zjistit, kolik miligram\u016f \u010dist\u00e9ho psilocybinu je t\u0159eba k v\u00fdrob\u011b psilocybinu pou\u017e\u00edt. <em>(u\u017e\u00edv\u00e1 se sublingv\u00e1ln\u011b prost\u0159ednictv\u00edm filmov\u00fdch prou\u017ek\u016f)<\/em> odpov\u00eddaj\u00ed standardn\u00ed d\u00e1vce 25 mg v tobolce. Konkr\u00e9tn\u011b budou testov\u00e1ny d\u00e1vky 1, 3, 5 a 7 mg. Ve f\u00e1zi 2B pak bude testov\u00e1na spr\u00e1vn\u00e1 sublingv\u00e1ln\u00ed d\u00e1vka oproti placebu u 120 \u00fa\u010dastn\u00edk\u016f s velkou depresivn\u00ed poruchou. <em>(MDD)<\/em>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-easier-times-ahead-for-patients-and-their-caregivers\"><em> Pacienty a jejich pe\u010dovatele \u010dekaj\u00ed leh\u010d\u00ed \u010dasy? <\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Snadnost, pohodl\u00ed a komfort.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To jsou v\u011bci, kter\u00e9 n\u011bkdy m\u016f\u017eeme pova\u017eovat za samoz\u0159ejm\u00e9. T\u011b\u0161\u00edme se z jednoduch\u00fdch \u017eivotn\u00edch radost\u00ed, jako je \u010dtvrtlibr\u00e1k se s\u00fdrem nebo ledov\u011b vychlazen\u00fd p\u016fllitr piva. Dop\u0159\u00e1v\u00e1me si luxus \u010dasu, luxus, kter\u00fd si pacienti v... <a aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\" href=\"https:\/\/www.who.int\/cancer\/palliative\/definition\/en\/\" target=\"_blank\" rel=\"noreferrer noopener\">paliativn\u00ed p\u00e9\u010de<\/a> nemus\u00ed b\u00fdt poskytnuta.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Proto je pro v\u011bdce tak d\u016fle\u017eit\u00e9 inovovat, aby psychedelick\u00fd v\u00fdzkum. <em>(nebo obecn\u011b l\u00e9ka\u0159sk\u00fd v\u00fdzkum)<\/em> usilovat o to, aby byly z\u00e1\u017eitky t\u011bchto pacient\u016f snesiteln\u011bj\u0161\u00ed.  Jednoduch\u00e9 v\u011bci, jako je zkr\u00e1cen\u00ed \u010dekac\u00ed doby, mohou u\u0161et\u0159it cenn\u00e9 vte\u0159iny z ka\u017edodenn\u00ed rutiny pacienta - kter\u00e9 by m\u011bl str\u00e1vit v pohodl\u00ed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tato nov\u00e1 technologie psilocybinov\u00fdch prou\u017ek\u016f je dal\u0161\u00edm krokem k legitimit\u011b i \u00fa\u010dinnosti psychedelick\u00e9 l\u00e9\u010dby... bude hr\u00e1t d\u016fle\u017eitou roli v budouc\u00ed medic\u00edn\u011b, zejm\u00e9na v p\u00e9\u010di o pacienty na konci \u017eivota.&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>P\u0159\u00edslib psychedelik je s ka\u017ed\u00fdm pr\u016flomem ve v\u00fdzkumu jasn\u011bj\u0161\u00ed. Nap\u0159\u00edklad terapie MDMA pro pacienty s posttraumatickou stresovou poruchou nebo mikrod\u00e1vkov\u00e1n\u00ed psilocybinu v boji proti depresi a \u00fazkosti. A vzpom\u00edn\u00e1te si, jak Kanada povolila u\u017e\u00edv\u00e1n\u00ed psilocybinu p\u0159i p\u00e9\u010di o pacienty v z\u00e1v\u011bru \u017eivota?\u00a0<\/p>","protected":false},"author":1,"featured_media":14865,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[],"topics":[],"class_list":["post-14862","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-culture"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/14862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/comments?post=14862"}],"version-history":[{"count":1,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/14862\/revisions"}],"predecessor-version":[{"id":123816,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/14862\/revisions\/123816"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media\/14865"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media?parent=14862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/categories?post=14862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/tags?post=14862"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/topics?post=14862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}