{"id":15803,"date":"2020-10-27T16:31:00","date_gmt":"2020-10-27T16:31:00","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=15165"},"modified":"2023-11-02T13:33:55","modified_gmt":"2023-11-02T12:33:55","slug":"anti-inflammatory-compound-found-in-psychedelics","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/cs\/blog\/protizanetlive-latky-obsazene-v-psychedelikach\/","title":{"rendered":"Protiz\u00e1n\u011btliv\u00e1 slou\u010denina nalezen\u00e1 v psychedelik\u00e1ch"},"content":{"rendered":"<\/p>\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-anti-inflammatory-compound-found-in-psychedelics\"><em>Protiz\u00e1n\u011btliv\u00e1 slou\u010denina nalezen\u00e1 v psychedelik\u00e1ch<\/em><\/h2>\n\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Siln\u00e9 psychedelick\u00e9 slou\u010deniny, jako nap\u0159.&nbsp;<a href=\"https:\/\/staging.wholecelium.com\/cs\/wiki\/mykologie-2\/co-je-psilocybin-2\/\" target=\"_blank\" rel=\"noopener\">psilocybin<\/a>&nbsp;<em>(od <strong>magick\u00e9 houby<\/strong>)<\/em>, <strong>DMT<\/strong> a <strong>LSD<\/strong> z\u00edskaly v posledn\u00edch letech podporu v\u011bdy. Bylo publikov\u00e1no mnoho v\u00fdzkum\u016f, kter\u00e9 p\u0159esn\u011b ukazuj\u00ed.<strong> jak mohou psychedelika p\u016fsobit protiz\u00e1n\u011btliv\u011b.<\/strong>.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Nyn\u00ed v\u011bdci z<strong> Centrum zdravotnick\u00fdch v\u011bd Louisiansk\u00e9 st\u00e1tn\u00ed univerzity<\/strong> objevili slou\u010deninu zvanou <strong>2C-H<\/strong>. P\u0159i testech bylo zji\u0161t\u011bno, \u017ee tato l\u00e1tka m\u00e1 nejlep\u0161\u00ed protiz\u00e1n\u011btliv\u00e9 v\u00fdsledky. Uk\u00e1zalo se, \u017ee 2C-H je na molekul\u00e1rn\u00ed \u00farovni velmi podobn\u00fd psychedelick\u00e9 droze 2C-B.<em>. <\/em><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-there-s-always-space-for-serotonin\"><em>Pro serotonin se v\u017edycky najde m\u00edsto<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Psychedelick\u00e9 drogy vyvol\u00e1vaj\u00ed sv\u016fj po\u017eadovan\u00fd \u00fa\u010dinek na mozek t\u00edm, \u017ee se p\u0159ipojuj\u00ed k <strong>serotoninov\u00fd receptor<\/strong> v mozku, kter\u00fd se naz\u00fdv\u00e1 <strong><a href=\"https:\/\/en.wikipedia.org\/wiki\/5-HT_receptor\" target=\"_blank\" rel=\"noreferrer noopener\">5HT-2A<\/a><\/strong>.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\">Serotonin<\/a><\/strong>, zn\u00e1m\u00fd tak\u00e9 jako \"hormon \u0161t\u011bst\u00ed\", sni\u017euje z\u00e1n\u011bt v imunitn\u00edch bu\u0148k\u00e1ch t\u011bla. Proto \u010d\u00edm v\u00edce serotoninu se vylu\u010duje, t\u00edm l\u00e9pe pro pacienty s onemocn\u011bn\u00edmi, jako je nap\u0159. <strong>astma<\/strong> a<strong> artritida<\/strong>.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-now-think-of-psychedelics-as-a-substitute-for-serotonin\"><em>Nyn\u00ed p\u0159em\u00fd\u0161lejte o psychedelik\u00e1ch jako o n\u00e1hra\u017ece serotoninu&nbsp;<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Stejn\u011b jako serotonin i psychedelick\u00e9 drogy vyvol\u00e1vaj\u00ed receptor 5HT-2A. L\u00e1tky, jako je psilocybin, tedy mohou pom\u00e1hat sni\u017eovat i z\u00e1n\u011bt. Ale tady je ta zvl\u00e1\u0161tn\u00ed \u010d\u00e1st. 2C-H - a\u010dkoli je v psychedelik\u00e1ch p\u0159\u00edtomen - s\u00e1m o sob\u011b nem\u00e1 absolutn\u011b \u017e\u00e1dn\u00e9 psychoaktivn\u00ed \u00fa\u010dinky...<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-2c-h-a-psychedelic-compound-without-the-high\"><em>2C-H: psychedelick\u00e1 slou\u010denina bez opojen\u00ed <\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"406\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-1024x406.png\" alt=\"diagram potkan\u016f s viditeln\u00fdmi pl\u00edcemi ukazuje protiz\u00e1n\u011btliv\u00e9 vlastnosti 2-CH\" class=\"wp-image-159637\" srcset=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-1024x406.png 1024w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-600x238.png 600w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-300x119.png 300w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-768x305.png 768w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-1536x609.png 1536w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-18x7.png 18w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram.png 1720w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>V\u011bdci potvrdili \u00fa\u010dinnost 2-CH na modelu astmatu u potkan\u016f. V\u0161imn\u011bte si, \u017ee protiz\u00e1n\u011btliv\u00fd aspekt 2-CH p\u016fsob\u00ed odd\u011blen\u011b od \"trippy\" efektu. To otev\u00edr\u00e1 mo\u017enost \"netripov\u00e9\" zku\u0161enosti pro pacienty s astmatem, kte\u0159\u00ed v sou\u010dasnosti u\u017e\u00edvaj\u00ed psilocybin pro \u00falevu.<\/em> <strong>Foto s laskav\u00fdm svolen\u00edm: ACS Pharmacol.<\/strong><\/figcaption><\/figure>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">V\u011bdci testovali 21 r\u016fzn\u00fdch slou\u010denin na potkanech s p\u0159\u00edznaky astmatu.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\"><em>(To bylo provedeno za \u00fa\u010delem ov\u011b\u0159en\u00ed p\u0159\u00edpadn\u00e9 souvislosti mezi <strong>\"kanonick\u00e9 sign\u00e1ln\u00ed dr\u00e1hy\"<\/strong> kter\u00fd se postar\u00e1 o \"trippy\" \u010d\u00e1st a po\u017eadovan\u00fd protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek.)<\/em><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Proto\u017ee v\u0161echny psychedelick\u00e9 slou\u010deniny aktivovaly receptor 5HT-2A, mnoh\u00e9 z nich byly schopny zabr\u00e1nit <em>(a dokonce i obr\u00e1cen\u011b)<\/em> z\u00e1n\u011bt v plic\u00edch. A h\u00e1dejte co? Protiz\u00e1n\u011btliv\u00e9 \u00fa\u010dinky 2-CH v\u016fbec nekoreluj\u00ed s \"behavior\u00e1ln\u00ed aktivitou\" ani s vybo\u010den\u00edm... v\u016fbec.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\"><em>\"Psychedelick\u00e9 drogy mohou m\u00edt siln\u00fd protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek. Zd\u00e1 se v\u0161ak, \u017ee protiz\u00e1n\u011btliv\u00e9 \u00fa\u010dinky nekoreluj\u00ed s behavior\u00e1ln\u00ed aktivitou, co\u017e nazna\u010duje r\u016fzn\u00e9 z\u00e1kladn\u00ed mechanismy.\" <\/em><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">- z <strong>ACS Pharmacology &amp; Translational Science (2020) <\/strong><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-testing-2c-h-for-inflammation-in-allergic-asthma\"><em>Testov\u00e1n\u00ed 2C-H na z\u00e1n\u011bt u alergick\u00e9ho astmatu<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">21 <strong>agonist\u00e9<\/strong> <em>(nebo l\u00e9ky, kter\u00e9 se v\u00e1\u017eou na receptor a aktivuj\u00ed jej).<\/em> byly vybr\u00e1ny ze 3 z\u00e1kladn\u00edch chemotyp\u016f na z\u00e1klad\u011b jejich schopnosti p\u0159edch\u00e1zet p\u0159\u00edznak\u016fm astmatu.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Mezi tyto p\u0159\u00edznaky pat\u0159\u00ed:<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>Du\u0161nost<\/strong><\/li>\n<li><strong>Tlak nebo bolest na hrudi<\/strong><\/li>\n<li><strong>s\u00edp\u00e1n\u00ed p\u0159i v\u00fddechu (\u010dast\u00e9 u astmatick\u00fdch d\u011bt\u00ed).<\/strong><\/li>\n<li><strong>Probl\u00e9my se sp\u00e1nkem zp\u016fsoben\u00e9 du\u0161nost\u00ed, ka\u0161lem nebo s\u00edp\u00e1n\u00edm<\/strong><\/li>\n<\/ul>\n<p>\n\n\n<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"735\" height=\"1024\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-735x1024.png\" alt=\"Sn\u00edmky plic potkan\u016f, kter\u00e9 ukazuj\u00ed, jak 2-CH m\u016f\u017ee zabr\u00e1nit z\u00e1n\u011btu a nadprodukci hlenu. \" class=\"wp-image-159641\" srcset=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-735x1024.png 735w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-600x835.png 600w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-215x300.png 215w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-768x1069.png 768w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-9x12.png 9w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH.png 958w\" sizes=\"(max-width: 735px) 100vw, 735px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Inhalace 2C-H m\u016f\u017ee pomoci zabr\u00e1nit z\u00e1n\u011btu a nadprodukci hlenu. Na obr\u00e1zku v\u00fd\u0161e jsou skute\u010dn\u00e9 d\u00fdchac\u00ed cesty \"astmatick\u00fdch\" potkan\u016f (l\u00e9\u010den\u00fdch 2C-H). Foto s laskav\u00fdm svolen\u00edm: ACS Pharmacol.<\/mark><\/em><\/figcaption><\/figure>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">V\u011bdci zjistili, \u017ee 2-CH je \"nejaktivn\u011bj\u0161\u00ed\" \u010d\u00e1st\u00ed molekul\u00e1rn\u00ed struktury pro protiz\u00e1n\u011btlivou aktivitu.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Pozornost v\u011bnovan\u00e1 2CH by mohla zkr\u00e1tit z\u00e1vod farmaceutick\u00fdm spole\u010dnostem, kter\u00e9 se nyn\u00ed sna\u017e\u00ed prosadit na trhu. <strong>vlna psychedelik v hlavn\u00edm proudu<\/strong>. Te\u010f u\u017e v\u011bd\u00ed, na kterou chemickou l\u00e1tku se mohou zam\u011b\u0159it.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-what-this-could-mean-for-anti-inflammatory-drugs-in-the-future\"><em>Co by to mohlo znamenat pro protiz\u00e1n\u011btliv\u00e9 l\u00e9ky v budoucnosti<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">V sou\u010dasn\u00e9 dob\u011b je mnoho lid\u00ed v d\u016fsledku pandemie COVID19 bez pen\u011bz. Krom\u011b ztr\u00e1ty p\u0159\u00edjmu z d\u016fvodu pracovn\u00ed neschopnosti se mnoz\u00ed ocitli tak\u00e9 mimo zdravotn\u00ed poji\u0161t\u011bn\u00ed.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Udr\u017eovac\u00ed l\u00e9ky na chronick\u00e9 onemocn\u011bn\u00ed, jako je astma, nejsou levn\u00e9 - p\u0159edepsan\u00e9 inhal\u00e1tory stoj\u00ed nejm\u00e9n\u011b. <strong>$496<\/strong> <strong>ka\u017ed\u00fd<\/strong>. Na\u0161t\u011bst\u00ed l\u00e9ka\u0159i nyn\u00ed postupn\u011b zva\u017euj\u00ed<strong> <a href=\"https:\/\/www.healtheuropa.eu\/psychedelics-association-to-bridge-medical-establishment-and-industry-gap\/102885\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\">mo\u017enosti psychedelick\u00e9 l\u00e9\u010dby pro sv\u00e9 pacienty<\/a><\/strong>.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Ned\u00e1vn\u00fd objev 2-CH by mohl v bl\u00edzk\u00e9 budoucnosti znamenat \u0159adu nov\u00fdch n\u00e1vrh\u016f protiz\u00e1n\u011btliv\u00fdch l\u00e9k\u016f.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Sledujte tento prostor!<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\n<p>\n\n\n<\/p>","protected":false},"excerpt":{"rendered":"<p>I kdy\u017e to b\u011b\u017en\u00e9mu u\u017eivateli mo\u017en\u00e1 nep\u0159ijde, v\u011bdci ji\u017e n\u011bjakou dobu zkoumaj\u00ed potenci\u00e1ln\u00ed protiz\u00e1n\u011btliv\u00e9 vlastnosti psychedelick\u00fdch drog. Jejich v\u00fdzkum nyn\u00ed jasn\u011b uk\u00e1zal, \u017ee psychedelika mohou pom\u00e1hat v boji proti z\u00e1n\u011bt\u016fm v t\u011ble.\u00a0<\/p>","protected":false},"author":1,"featured_media":15818,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-15803","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/15803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/comments?post=15803"}],"version-history":[{"count":6,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/15803\/revisions"}],"predecessor-version":[{"id":159643,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/15803\/revisions\/159643"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media\/15818"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media?parent=15803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/categories?post=15803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/tags?post=15803"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/topics?post=15803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}