{"id":16583,"date":"2021-01-12T15:10:37","date_gmt":"2021-01-12T15:10:37","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=16583"},"modified":"2023-11-02T16:58:39","modified_gmt":"2023-11-02T15:58:39","slug":"what-is-salvia-salvinorin-a","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/cs\/blog\/co-je-salvia-salvinorin-a\/","title":{"rendered":"Co je Salvia (Salvinorin A)?"},"content":{"rendered":"

 <\/strong><\/p>\n\n\n\n

Psychedelika dnes u\u017e\u00edv\u00e1 \u0161irok\u00e9 spektrum spole\u010dnosti - od mikrod\u00e1vkov\u00e1n\u00ed<\/a> matk\u00e1m, lidem, kte\u0159\u00ed se sna\u017e\u00ed uniknout uzav\u0159en\u00ed - i kdyby jen proto, aby mohli cestovat v my\u0161lenk\u00e1ch. <\/p>\n\n\n\n

Mo\u017en\u00e1 nejste kmenov\u00fd mudrc, ale mo\u017en\u00e1 chcete v\u011bd\u011bt n\u011bco v\u00edc o \u0161irok\u00e9 \u0161k\u00e1le l\u00e1tek vyvol\u00e1vaj\u00edc\u00edch vid\u011bn\u00ed? Tak my jsme tu, abychom v\u00e1m p\u0159edstavili dal\u0161\u00ed z nich - Miley Cyrus'<\/a> halucinogeny pro dosp\u00edvaj\u00edc\u00ed - mexick\u00e1 droga pro domorodce Salvinorin A<\/strong> (pravd\u011bpodobn\u011b ji zn\u00e1te pod n\u00e1zvem Salvia).<\/em><\/p>\n\n\n\n

V\u011bdci z Univerzity Johnse Hopkinse zrentgenovali mozky t\u011bch, kte\u0159\u00ed m\u011bli... vaped Salvinorin A <\/a><\/strong>. Potvrdili, \u017ee salvinorin A p\u016fsob\u00ed podobn\u011b jako jin\u00e1 psychedelika, nap\u0159. psilocybin, MDMA a LSD, a to tak, \u017ee zp\u016fsobuje. nov\u00e1 spojen\u00ed v mozku<\/strong>. <\/p>\n\n\n\n

V\u011bdci pak zjistili, \u010d\u00edm je salvinorin A tak v\u00fdjime\u010dn\u00fd. Spou\u0161t\u011bl v\u00edce n\u00e1hodn\u00fd<\/strong>, odpojen\u00e9 sign\u00e1ly<\/strong>, ale v pozitivn\u00edm smyslu. <\/p>\n\n\n\n

Ne, studie si uv\u011bdomila. Salvinorin A nen\u00ed pouhou p\u00e1rty drogou - je to p\u0159\u00edrodn\u00ed plyn k sm\u00edchu!<\/p>\n\n\n\n

Sm\u011bj\u00edc\u00ed se plyn p\u0159\u00edrody <\/em><\/h2>\n\n\n\n

Salvinorin A je halucinogen z\u00edsk\u00e1van\u00fd z rostliny. Salvia divinorum<\/strong>. Poskytuje intenzivn\u00ed \"plovouc\u00ed\"<\/em> pocity a jakousi kr\u00e1tkodobou amn\u00e9zii - podobn\u011b jako u oxidu dusn\u00e9ho (neboli \"sm\u011b\u0161n\u00e9ho plynu\") u zuba\u0159e.<\/p>\n\n\n\n

\"Salvinorin
Naprosto bo\u017esk\u00e9! Detail kv\u011btu \u0161alv\u011bje bo\u017esk\u00e9 (Salvia divinorum). (Se svolen\u00edm: Wikimedia Commons)<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Manoj Doss, Ph.D.<\/strong>, postdoktorand na kated\u0159e psychedelik a v\u00fdzkumu v\u011bdom\u00ed na Johns Hopkins, \u0159ekl:<\/p>\n\n\n\n

\"Zd\u00e1 se, \u017ee salvinorin A d\u011bl\u00e1 v\u0161echny ty v\u011bci, o kter\u00fdch se v\u011bdci domn\u00edvaj\u00ed, \u017ee se d\u011bj\u00ed p\u0159i p\u016fsoben\u00ed jin\u00fdch psychedelik (jako je LSD a psilocybin) na mozek. <\/em><\/p>\n\n\n\n

\"Vtipn\u00e9 je, \u017ee n\u011bkte\u0159\u00ed v\u00fdzkumn\u00edci se selektivn\u011b zam\u011b\u0159ili na s\u00ed\u0165 v\u00fdchoz\u00edho re\u017eimu, i kdy\u017e pr\u00e1v\u011b v n\u00ed nenach\u00e1zej\u00ed nejsiln\u011bj\u0161\u00ed \u00fa\u010dinky klasick\u00fdch psychedelik. <\/em><\/p>\n\n\n\n

\"Naopak, pr\u00e1v\u011b tam jsme zjistili nejsiln\u011bj\u0161\u00ed \u00fa\u010dinky salvinorinu A.\"<\/em><\/p>\n\n\n\n

Mudrc a mudrci <\/em><\/h2>\n\n\n\n

Salvinorin A je stejn\u011b jako psilocybin z\u00edskan\u00fd p\u0159irozenou cestou<\/strong>. Z\u00edsk\u00e1v\u00e1 se z rostliny \u0161alv\u011bje l\u00e9ka\u0159sk\u00e9 (Salvia Divinorum). Salvinorin A m\u00e1 p\u0159i u\u017e\u00edv\u00e1n\u00ed lidmi rychl\u00fd n\u00e1stup \u00fa\u010dinku. (nebo za jak dlouho se \"rozb\u011bhne\").<\/em> V\u00fdlet je kr\u00e1tk\u00fd, ale siln\u00fd... s mimot\u011bln\u00edmi pocity, halucinacemi, a... odtr\u017een\u00ed od reality. <\/strong><\/p>\n\n\n\n

Na rozd\u00edl od psilocybinu a LSD v\u0161ak salvinorin A neinteraguje s jin\u00fdmi l\u00e1tkami. serotonin-2A<\/strong> - receptor v mozku, kter\u00fd \u0159\u00edd\u00ed u\u010den\u00ed, chu\u0165 k j\u00eddlu a dal\u0161\u00ed aktivn\u00ed t\u011blesn\u00e9 procesy. Ve skute\u010dnosti se v\u00e1\u017ee na kappa-opioidn\u00ed receptor, kter\u00fd sni\u017euje hladinu dopaminu. To vyvol\u00e1v\u00e1 pocit dysforie (co\u017e je opak euforie, tak\u017ee to nen\u00ed dobr\u00e9). <\/em>Z tohoto d\u016fvodu mnoho lid\u00ed \u0159\u00edk\u00e1, \u017ee trip se \u0161alv\u011bj\u00ed je obt\u00ed\u017en\u00e9<\/em> u\u017e\u00edt si.<\/p>\n\n\n\n

Pat\u0159\u00ed do \u010deledi m\u00e1tovit\u00fdch, Salvia divinorum <\/em>je historicky obl\u00edben\u00fd Mazat\u00e9kov\u00e9 <\/strong>v mexick\u00e9m m\u011bst\u011b Oaxaca. Po stovky let u\u017e\u00edvali tuto psychoaktivn\u00ed rostlinu p\u0159i ritu\u00e1lech mazate\u010dt\u00ed mudrci. <\/p>\n\n\n\n

Dnes, Salvia divinorum<\/em> lze nal\u00e9zt v\u0161ude v Kalifornii, kde je od roku 2009 leg\u00e1ln\u00edm psychedelikem. M\u00edstn\u00ed obyvatel\u00e9 si pochutn\u00e1vaj\u00ed na S. divinorum<\/em> jako quid<\/strong>, co\u017e je n\u011bco jako \u017ev\u00fdkac\u00ed tab\u00e1k. Salvia se tak\u00e9 kou\u0159\u00ed v tradici tr\u00e1vy, nicm\u00e9n\u011b kv\u016fli sv\u00fdm p\u0159ev\u00e1\u017en\u011b dezorientuj\u00edc\u00edm a nep\u0159\u00edjemn\u00fdm \u00fa\u010dink\u016fm se nikdy nestala tak roz\u0161\u00ed\u0159enou jako jin\u00e1 psychedelika, jako je psilocybin a LSD. <\/p>\n\n\n\n

Nejsiln\u011bj\u0161\u00ed p\u0159\u00edrodn\u00ed halucinogen<\/em> <\/h2>\n\n\n\n
\"mozek
Salvinorin A ovliv\u0148uje oblasti mozku, kter\u00e9 jsou nejaktivn\u011bj\u0161\u00ed, kdy\u017e nejste du\u0161evn\u011b zam\u011bstn\u00e1ni (zn\u00e1zorn\u011bno \u010derven\u011b). Nap\u0159\u00edklad kdy\u017e doma odpo\u010d\u00edv\u00e1te nebo se b\u011bhem vyu\u010dov\u00e1n\u00ed rozpt\u00fdl\u00edte. (Se svolen\u00edm: Johns Hopkins Medicine)<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Hlavn\u00ed agonista <\/strong>(nebo \"tripper\") <\/em>z Salvia divinorum<\/em> je salvinorin A. M\u00e1 tak\u00e9 velmi unik\u00e1tn\u00ed chemick\u00e1 struktura<\/strong>, na rozd\u00edl od jin\u00fdch halucinogen\u016f vyskytuj\u00edc\u00edch se v p\u0159\u00edrod\u011b, jako je psilocybin, peyotl a DMT. Salvinorin A se samoz\u0159ejm\u011b tak\u00e9 chemicky li\u0161\u00ed od laboratorn\u011b vyroben\u00fdch halucinogen\u016f - nap\u0159\u00edklad LSD a ketaminu. <\/p>\n\n\n\n

Salvinorin A tak\u00e9 \"zamrzne\"<\/em> na m\u00edst\u011b, zejm\u00e9na p\u0159i vdechov\u00e1n\u00ed. \u00da\u010dinky lze popsat jako snov\u00fd z\u00e1\u017eitek bl\u00edzk\u00fd smrti<\/strong>.<\/p>\n\n\n\n

Jak siln\u00fd je salvinorin A ve skute\u010dnosti? <\/p>\n\n\n\n

Salvinorin A je p\u0159i kou\u0159en\u00ed <\/strong>the<\/em> <\/strong>nejsiln\u011bj\u0161\u00ed p\u0159\u00edrodn\u00ed halucinogen. Jedin\u00e1 d\u00e1vka u lid\u00ed (v rozmez\u00ed od 200 do 1 000 \u03bcg)<\/em> se vyrovn\u00e1 LSD v tom, jak p\u016fsob\u00ed na va\u0161e smysly. Trip p\u0159ich\u00e1z\u00ed po 1 minut\u011b<\/strong>a trv\u00e1 15 minut<\/strong> v pr\u016fm\u011bru. <\/p>\n\n\n\n

Mrkni a pro\u0161vihne\u0161 to!<\/p>\n\n\n\n

Psychedelick\u00fd vaping <\/em><\/h2>\n\n\n\n

V r\u00e1mci studie bylo \u00fa\u010dastn\u00edk\u016fm sd\u011bleno, \u017ee z\u00edskaj\u00ed pom\u011brn\u011b vysok\u00e1 d\u00e1vka<\/strong> salvinorinu A. Ne\u017e jim byla pod\u00e1na samotn\u00e1 droga, n\u011bkolikr\u00e1t si procvi\u010dili, jak vapovat, se speci\u00e1ln\u00edmi pokyny: \"Lehn\u011bte si na z\u00e1da, nasa\u010fte si klapky na o\u010di a poslouchejte hudbu!\"<\/em><\/p>\n\n\n\n

12 mu\u017e\u016f vapovalo krystalky salvinorinu A a hned pot\u00e9 byli sn\u00edm\u00e1ni pomoc\u00ed fMRI (nebo funk\u010dn\u00ed magnetick\u00e1 rezonance<\/strong>) po dobu n\u00e1sleduj\u00edc\u00edch 15 minut, abychom zjistili, jak v\u00fdlet ovlivnil jejich mozek.<\/p>\n\n\n\n

V\u00fdzkumn\u00edci pou\u017eili 8 mozkov\u00fdch s\u00edt\u00ed <\/strong>jako v\u00fdchoz\u00ed, a to: 3 s\u00edt\u011b pro zrak a 5 dal\u0161\u00edch pro pohyb a dotek, pozornost, odm\u011bnu a schopnost vn\u00edmat. \"v\u00fdchoz\u00ed re\u017eim s\u00edt\u011b\"<\/strong> (nebo mysl v klidu)<\/em>. <\/p>\n\n\n\n

A tady je ta zaj\u00edmavost. Dalo by se o\u010dek\u00e1vat, \u017ee \"symfonie\"<\/em> v\u0161ech 8 mozkov\u00fdch s\u00edt\u00ed. Salvinorin A je p\u0159ece psychedelikum, ne? <\/p>\n\n\n\n

V\u011bdci v\u0161ak zjistili, \u017ee nejen mozkov\u00e9 aktivity. pauza<\/strong> <\/em>sign\u00e1ly se prozat\u00edm staly n\u00e1hodn\u00fdmi a nep\u0159edv\u00eddateln\u00fdmi. <\/p>\n\n\n\n

(Kli\u010dkov\u00e1n\u00ed. Kli\u010dkov\u00e1n\u00ed. Po\u010dkat, testovan\u00fd subjekt \u010d. 9 se sm\u011bje?<\/em>)<\/p>\n\n\n\n

Potenci\u00e1l pro l\u00e9\u010dbu z\u00e1vislosti <\/em><\/h2>\n\n\n\n

Salvinorin A je navzdory sv\u00fdm z\u0159eteln\u00fdm odli\u0161nostem od ostatn\u00edch \"klasick\u00fdch\" psychedelik st\u00e1le jednou z nov\u00fdch hv\u011bzd farmaceutick\u00e9ho pr\u016fmyslu. <\/em>kv\u016fli jeho skute\u010dn\u00e9mu potenci\u00e1lu v l\u00e9\u010db\u011b z\u00e1vislosti. Ibogain<\/strong> (p\u0159\u00edbuzn\u00fd salvinorinu A)<\/em> prok\u00e1zal \u00fa\u010dinnost jako l\u00e9\u010dba zneu\u017e\u00edv\u00e1n\u00ed kokainu a opioid\u016f<\/strong>v preklinick\u00e9m modelu. <\/p>\n\n\n\n

V\u011bdci brzy zah\u00e1j\u00ed novou studii, aby zjistili, jak salvinorin A skute\u010dn\u011b srovn\u00e1v\u00e1<\/strong> terapeuticky k obl\u00edben\u00fdm halucinogenn\u00edm drog\u00e1m, jako je psilocybin a LSD. <\/p>\n\n\n\n

Co si mysl\u00edte? Je pro \u0161alv\u011bj m\u00edsto u stolu psychedelick\u00e9 medic\u00edny? <\/p>\n\n\n\n

Pod\u011blte se o sv\u00e9 n\u00e1zory n\u00ed\u017ee!<\/em><\/p>","protected":false},"excerpt":{"rendered":"

Psychedelika byla v\u017edy spojov\u00e1na se starov\u011bk\u00fdmi kulturami.\u00a0<\/p>\n

Sages took psychedelics in a ritual setting, to see visions of truth in smoke and fire. Native Mexicans brewed peyote and San Pedro cactus, and the Amazonian tribes drank ayahuasca.<\/p>","protected":false},"author":1,"featured_media":16584,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-16583","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/16583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/comments?post=16583"}],"version-history":[{"count":2,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/16583\/revisions"}],"predecessor-version":[{"id":159774,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/16583\/revisions\/159774"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media\/16584"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/media?parent=16583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/categories?post=16583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/tags?post=16583"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/cs\/wp-json\/wp\/v2\/topics?post=16583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}