{"id":16462,"date":"2020-12-18T09:12:03","date_gmt":"2020-12-18T09:12:03","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=16462"},"modified":"2023-11-02T15:41:30","modified_gmt":"2023-11-02T14:41:30","slug":"first-dmt-trial-for-major-depression","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/da\/blog\/first-dmt-trial-for-major-depression\/","title":{"rendered":"F\u00f8rste DMT-fors\u00f8g mod sv\u00e6r depression"},"content":{"rendered":"<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Ogs\u00e5 kendt som <strong>N,N-Dimethyltryptamin<\/strong>DMT er kendt for sine intense trips, der dykker dybt ned i den \u00e5ndelige vildmark. Mens DMT kan findes i de fleste planter og v\u00e6sner, er det kendt for sin ber\u00f8mmelse i forbindelse med <strong>Ayahuasca<\/strong> - en psykedelisk te fra den amazoniske vinplante af samme navn. I hundredvis af \u00e5r har lokale stammer i Amazonas drukket DM-Tea <em>(forst\u00e5r du?)<\/em> at helbrede sygdomme i sind, krop og sj\u00e6l.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Er det p\u00e5 tide at unders\u00f8ge DMT med rigtige levende patienter? M\u00e5ske bane vejen for en lovlig og udbredt brug af det? Lad os finde ud af det!<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-lasting-changes-in-brain-function\"><em>Varige \u00e6ndringer i hjernefunktionen <\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">En enkelt dosis Ayahuasca kan skabe varige \u00e6ndringer i hjernefunktionen. En person med en tendens til at v\u00e6re st\u00e6dig bliver for eksempel \u00e5ben for forandring. Denne s\u00e5kaldte <em>\"hjernens fleksibilitet\"<\/em> for\u00e5rsaget af DMT kan ogs\u00e5<strong>&nbsp;<\/strong><a href=\"https:\/\/staging.wholecelium.com\/da\/blog\/dmt-for-behandlingsresistent-depression\/\" target=\"_blank\" rel=\"noopener\"><b>\u00e6ndre depressive symptomer<\/b><\/a><strong>.  <\/strong><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Men det er Ayahuasca, hvis virkning kan vare op til 8 timer. P\u00e5 den anden side, <strong>ren DMT<\/strong> <em>(uanset om det er r\u00f8get eller injiceret)<\/em>, varer kun ca. 15-30 minutter. DMT-trips er m\u00e5ske korte, men de er vanvittigt st\u00e6rke. <em>Napoleons<\/em>, endda.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Forskere fra Johns Hopkins University fandt ud af, at 90% af dem, der har pr\u00f8vet DMT, sagde, at de var mere tilfredse med deres liv, mens 80% sagde, at deres DMT-tur <strong>\u00e6ndrede deres syn p\u00e5 virkeligheden for altid<\/strong>... ligesom i The Matrix.<\/p>\n<p>\n\n\n<\/p>\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"639\" height=\"356\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1.jpg\" alt=\"gl\u00f8dende synapse i hjernen\" class=\"wp-image-159727\" style=\"width:841px\" srcset=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1.jpg 639w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1-600x334.jpg 600w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1-300x167.jpg 300w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1-18x10.jpg 18w\" sizes=\"(max-width: 639px) 100vw, 639px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">via Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-faster-than-expected\"> <em>Hurtigere end forventet<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Fors\u00f8get, der g\u00e5r hurtigere end forventet ind i fase 1, er et samarbejde mellem <strong>Imperial College London<\/strong> og <strong>Sm\u00e5 l\u00e6gemidler<\/strong>, en virksomhed, der arbejder med hjernemedicin.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">CEO for sm\u00e5 l\u00e6gemidler <strong>Peter Rands<\/strong> sagde:<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\"><em>\"DMT giver en psykedelisk oplevelse p\u00e5 20 minutter og har unikke egenskaber. Ved at indf\u00f8re ansvarlig evidensbaseret forskning ... h\u00e5ber vi at kunne hj\u00e6lpe med at give disse engang stigmatiserede stoffer et nyt navn som meget effektive medicinske behandlinger.\"<\/em><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Hvis dette DMT-fors\u00f8g viser sig at v\u00e6re en succes, kan det fremme muligheden for at tilf\u00f8je psykedelisk baseret medicin i vores sundhedssystemer.  Dette betyder <strong>billigere, mere naturlige muligheder<\/strong> for millioner af mennesker, der lider af depression. Vi krydser fingre!<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-healthy-volunteers-first\"> <em>Sunde frivillige f\u00f8rst <\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Fase 1 starter i januar 2021. I denne fase vil fors\u00f8get teste DMT p\u00e5 raske frivillige <em>(som aldrig har pr\u00f8vet psykedeliske stoffer)<\/em> f\u00f8rst.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">P\u00e5 denne m\u00e5de kan unders\u00f8gelsen f\u00e5 en <strong>kontrolgruppe<\/strong> til sammenligning med patienter med depression <em>(ogs\u00e5 kendt som fase 2a)<\/em>. N\u00e5r s\u00e5danne frivillige lider af invaliderende lidelser som disse, betyder det naturligvis, at der er behov for et netv\u00e6rk af st\u00f8tte - b\u00e5de socialt og videnskabeligt.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"432\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-1024x432.jpeg\" alt=\"Magiske svampe p\u00e5 en farverig spiralbaggrund\" class=\"wp-image-159730\" srcset=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-1024x432.jpeg 1024w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-600x253.jpeg 600w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-300x127.jpeg 300w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-768x324.jpeg 768w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-1536x648.jpeg 1536w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-18x8.jpeg 18w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21.jpeg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-2021-the-year-of-legalization\"><em> 2021: Legaliseringens \u00e5r? <\/em><\/h2>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">DMT og psilocybin kan ses som n\u00e6re f\u00e6tre, da de begge er <strong><a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/tryptamines\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\">tryptaminer<\/a><\/strong>, hvilket betyder, at de har den samme brede molekyl\u00e6re familie. B\u00e5de DMT og psilocybin kildrer hjernens nerveender for at skabe en \u00e6ndret bevidsthedstilstand. Men kun psilocybin har den juridiske godkendelse <em>(i Oregon i hvert fald - andre f\u00f8lger snart efter)<\/em>. Hvad sker der s\u00e5?<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Her er detaljerne.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">F\u00f8r Oregon <a href=\"https:\/\/staging.wholecelium.com\/da\/articles\/psychedelic-culture\/oregon-votes-yes-to-psilocybin\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>godkendt<\/strong> <\/a>terapeutisk anvendelse af psilocybin, idet forbindelsen f\u00f8rst <em>\"vundet\"<\/em> i \u00f8jnene af forskere + store universiteter, s\u00e5som <strong>John Hopkins<\/strong>. Psilocybin-fors\u00f8g gav h\u00e5ndfaste beviser for, at det kan behandle resistent depression ... hvilket f\u00f8rte til dets <em>(vinder)<\/em> juridisk argument. Og en retlig pr\u00e6cedens er ikke en lille ting.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Det ser ud til, at DMT er det n\u00e6ste store psykedeliske stof at f\u00f8lge, baseret p\u00e5 dets nuv\u00e6rende kurs. Og hvem ved? Denne gang i slutningen af 2021 kan DMT ogs\u00e5 blive lovligt godkendt...<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/B411rHX7nUZjyljr7huxKnin5wuIztfKmCoE9dAVhr3jvODq9nCysQgz6gIkCa2W443VcbaOszqq59L-mOhEW7eYQjakpnGaayDRKn0SQExl_Nuzf-ct0ZX8Y91by-IMnHoaZQ2X\" alt=\"\"><\/figure>\n<p>\n\n\n\n\n\n\n<\/p>","protected":false},"excerpt":{"rendered":"<p>Psykonauterne har l\u00e6nge \u00e6ret det, men nu er det tid for resten af verden at f\u00f8lge med... For f\u00f8rste gang nogensinde vil kliniske patientfors\u00f8g med DMT begynde i januar 2021, om et par uger. De britiske forskere vil \u00e9n gang for alle bevise, at det s\u00e5kaldte \"\u00e5ndemolekyle\" er en lovlig behandling af sv\u00e6r depression ... og en v\u00e6rdig udfordrer som et af de st\u00e6rkeste psykedeliske stoffer p\u00e5 planeten.\u00a0<\/p>","protected":false},"author":1,"featured_media":17812,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-16462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/posts\/16462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/comments?post=16462"}],"version-history":[{"count":7,"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/posts\/16462\/revisions"}],"predecessor-version":[{"id":159735,"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/posts\/16462\/revisions\/159735"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/media\/17812"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/media?parent=16462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/categories?post=16462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/tags?post=16462"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/da\/wp-json\/wp\/v2\/topics?post=16462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}