{"id":14862,"date":"2020-10-17T16:58:00","date_gmt":"2020-10-17T16:58:00","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=14862"},"modified":"2023-05-11T14:16:00","modified_gmt":"2023-05-11T12:16:00","slug":"the-psilocybin-strips-changing-medicine","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/lt\/blog\/psilocibino-juosteles-keicia-medicina\/","title":{"rendered":"Psilocibino juostel\u0117s kei\u010dia medicin\u0105"},"content":{"rendered":"<h2 class=\"wp-block-heading\" id=\"h-the-psilocybin-strips-changing-medicine\"><em>Psilocibino juostel\u0117s kei\u010dia medicin\u0105<\/em><\/h2>\n\n\n\n\n\n<p class=\"wp-block-paragraph\">Be to, daugyb\u0117 did\u017eiuli\u0173, gerai vertinam\u0173 universitet\u0173 prad\u0117jo kurti savo psichodelikos tyrim\u0173 centrus, pvz., pra\u0117jus\u012f m\u0117nes\u012f Berklio Kalifornijos universiteto Psichodelikos mokslo centras.<strong>,<\/strong> Johns Hopkins\" 2019 m. atidarymas ir NYU Langone Health <a aria-label=\"neapibr\u0117\u017etas (atsidaro naujame skirtuke)\" href=\"https:\/\/cheddar.com\/media\/mindmed-psychedelics-nyu-langone-nasdaq-uplist\" target=\"_blank\" rel=\"noreferrer noopener\">art\u0117jantis padalinys<\/a>, ie\u0161kodami kito did\u017eiulio psichodelin\u0117s medicinos atradimo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u012esp\u016bdingos naujienos, tiesa? Palaukite, kol i\u0161girsite apie <a label=\"undefined (opens in a new tab)\" href=\"https:\/\/www.cybin.com\/cybin-corp-and-intelgenx-corp-enter-into-feasibility-agreement-for-fast-acting-orally-dissolving-psilocybin-film\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\"><em>Kybin's <\/em>naujas trupintuvas<\/a>: didel\u0117s doz\u0117s psilocibino pl\u0117vel\u0117, kuri tirpsta burnoje... tiesiogine prasme. Tai psilocibino juostel\u0117s, kei\u010dian\u010dios vaistus...<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-oral-vs-sublingual-intake-of-psilocybin\"><strong> <\/strong><em>Psilocibino vartojimas per burn\u0105 ir po lie\u017euviu <\/em><\/h2>\n\n\n\n<figure><img decoding=\"async\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/2020\/10\/mouths-scaled-1.jpg\" alt=\"\" \/><figcaption><mark><em>(Nuotraukos autoryst\u0117: \"IntelGenX\" svetain\u0117)<\/em><\/mark><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\"Cybin Corporation\" bendradarbiauja su <a aria-label=\"neapibr\u0117\u017etas (atsidaro naujame skirtuke)\" href=\"https:\/\/www.intelgenx.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">\"IntelGenx\"<\/a> <strong>,<\/strong> geriam\u0173j\u0173 vaist\u0173 pristatymo technologij\u0173 bendrov\u0117, kad <em>Psilotoninas\u2122<\/em> - pirmosios greitai tirpstan\u010dios juostel\u0117s su farmacin\u0117s kokyb\u0117s psilocibinu. 25 mg psilocibino pl\u0117vel\u0117s juostel\u0117s skirtos vartoti po lie\u017euviu <em>(arba \"po lie\u017euviu\")<\/em> skirtingai nuo daugumos klinikini\u0173 tyrim\u0173 ir psichodelini\u0173 terapij\u0173, kuriose naudojamos kapsul\u0117s.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Standartiniu vartojimo b\u016bdu psilocibinas turi pereiti per vir\u0161kinimo sistem\u0105, kad gal\u0117t\u0173 virsti psilocinu - biologi\u0161kai aktyviu junginiu, kuris veikia smegen\u0173 <em><a aria-label=\"neapibr\u0117\u017etas (atsidaro naujame skirtuke)\" href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\">\"laim\u0117s hormonas\"<\/a><\/em><strong><a aria-label=\"neapibr\u0117\u017etas (atsidaro naujame skirtuke)\" href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\"> <\/a><\/strong> receptoriai.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>(Papildoma pastaba: \u0160tai kod\u0117l kelion\u0117 paprastai u\u017etrunka ma\u017eiausiai 30 minu\u010di\u0173. Dabar \u017einote!)<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Taip pat verta pamin\u0117ti, kad 50-60% i\u0161 25 mg doz\u0117s prarandama, kai vartojama per burn\u0105, o tai rei\u0161kia, kad ji niekada nepatenka \u012f krauj\u0105... arba nepasiekia smegen\u0173.  Taip yra tod\u0117l, kad didel\u0117 dalis psilocino pirmiausia metabolizuojama kepenyse, o ne burnoje ar skrandyje.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kita vertus, kai psilocibino pl\u0117vel\u0117 i\u0161tirpsta po lie\u017euviu, ji gali praleisti \u012fprast\u0105 keli\u0105, kuriuo ji tampa \"biologi\u0161kai prieinama\". <em>(arba absorbuojamas ir panaudojamas organizme),<\/em> i\u0161 karto patenka \u012f krauj\u0105.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\"Cybin\" vyriausiasis gydytojas Jukka Karjalainenas sak\u0117:<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><p> <em>\"Naudojant geriam\u0105j\u0105 pl\u0117vel\u0119, biologinis prieinamumas padid\u0117ja iki 100%. Doz\u0117, kuri skiriama, yra klinikiniam poveikiui pasiekiama doz\u0117.\" <\/em><\/p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-is-your-gut-required-for-psilocybin-s-full-effect\"> <em>Ar j\u016bs\u0173 \u017earnynas reikalingas visi\u0161kam psilocibino poveikiui? <\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Laikykit\u0117s. Jei per burn\u0105 tirpstan\u010dios pl\u0117vel\u0117s doz\u0117 yra tik dalis kapsul\u0117ms reikalingos doz\u0117s, kok\u012f vaidmen\u012f vis dar atlieka \u017earnynas, kai kalbama apie psilocibin\u0105? Dr. Alanas Deivisas (Alan Davis), Johnso Hopkinso universiteto Psichodelikos tyrim\u0173 padalinio docentas, pateikia kelet\u0105 \u012f\u017evalg\u0173:<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><p> <em>\"Taip pat kyla abejoni\u0173 d\u0117l \u017earnyno svarbos psichikos sveikatos proces\u0173 sutrikimams.\"<\/em><\/p><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Davisas taip pat teig\u0117, kad \u017earnyno mikrobiomas, t. y. bakterij\u0173, pirmuoni\u0173 ir grybeli\u0173, esan\u010di\u0173 j\u016bs\u0173 organizme, visuma, gali tur\u0117ti \u012ftakos psichikos sveikatai. Tai daugiausia susij\u0119 su serotonino perne\u0161\u0117j\u0173 gausa. <em>(d\u0117l to \u012f smegenis patenka psilocinas)<\/em> \u017earnyno viduje.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-this-could-mean-for-patients\"><em>K\u0105 tai gali reik\u0161ti pacientams<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\"IntelGenX\" plonyt\u0117 plok\u0161tel\u0117 <a aria-label=\"neapibr\u0117\u017etas (atsidaro naujame skirtuke)\" href=\"https:\/\/www.intelgenx.com\/technology\/versafilm.html\" target=\"_blank\" rel=\"noreferrer noopener\">\"VersaFilm\" technologija<\/a> - kuris leid\u017eia greitai suirti nenaudojant vandens, turi daug reik\u0161m\u0117s ne tik psichodelikams, bet ir medicinai apskritai.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Universali vaist\u0173 tiekimo platforma, tokia kaip pl\u0117vel\u0117s juostel\u0117s, gal\u0117t\u0173 suteikti pacientams daugyb\u0119 kit\u0173 galim\u0173 privalum\u0173, pvz:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Greitesn\u0117 absorbcija per burn\u0105<\/strong> <em>(kai vaistas yra tarp danten\u0173 ir skruosto).<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Greitesn\u0117 absorbcija po lie\u017euviu<\/strong> <em>(\"po lie\u017euviu\")<\/em>.&#8221;<em>)<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Greitesn\u0117 veikimo prad\u017eia + didesnis biologinis prieinamumas<\/strong>.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Daugiau patogumo pacientams<\/strong> d\u0117l savo ma\u017eo ir plono dyd\u017eio.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Be to, praleidus pirmojo per\u0117jimo metabolizm\u0105, <em>\"k\u0105 dozuoji, t\u0105 ir gauni\"<\/em> - tod\u0117l yra <strong>\u012f krauj\u0105 \u012fsisavinama daugiau vaist\u0173.<\/strong> <em>(kitaip nei kapsul\u0117se)<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pl\u0117vel\u0117s juostel\u0117s taip pat puikiai tinka pacientams, kuriems sunku nuryti, kurie bijo u\u017espringti arba kuriuos kamuoja pykinimas nuo<strong> chemoterapija<\/strong> arba <strong>radioterapija<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Taip pat yra neribot\u0173 skonio galimybi\u0173, nes visas vartojimas vyksta skonio receptoriuose. <em>(M\u0117t\u0173 \u0161okolado skonio pl\u0117vel\u0117s juostel\u0117s? \"Cybin\" b\u016bt\u0173 beproti\u0161ka neeksperimentuoti)<\/em>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials-in-jamaica\"><em>Klinikiniai tyrimai Jamaikoje<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\"Cybin\" ketina atlikti bandymus Jamaikoje, vienoje i\u0161 laimingiausi\u0173 viet\u0173, kur psilocibinas yra legalus, i\u0161 viso 2 etapais: 2A ir 2B etapais. 2A etape tur\u0117t\u0173 b\u016bti tiksliai nustatyta, kiek miligram\u0173 gryno psilocibino <em>(vartojamas po lie\u017euviu per pl\u0117vel\u0117s juosteles)<\/em> atitinka standartin\u0119 25 mg doz\u0119 kapsul\u0117je. Konkre\u010diai bus tiriamos 1, 3, 5 ir 7 mg doz\u0117s. Po to 2B etape 120 dalyvi\u0173, sergan\u010di\u0173 did\u017eiuoju depresiniu sutrikimu, bus i\u0161bandyta tinkama po lie\u017euviu vartojama doz\u0117, lyginant j\u0105 su placebu. <em>(MDD)<\/em>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-easier-times-ahead-for-patients-and-their-caregivers\"><em> Pacient\u0173 ir j\u0173 slaugytoj\u0173 laukia lengvesni laikai? <\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Lengva, patogu ir komforti\u0161ka.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tai dalykai, kuriuos kartais galime laikyti savaime suprantamais. M\u0117gaujam\u0117s paprastais gyvenimo malonumais, tokiais kaip ketvir\u010dio pintin\u0117 su s\u016briu ar ledi\u0161kai \u0161alta pintin\u0117 alaus. Mes gauname laiko prabang\u0105, prabang\u0105, kuri\u0105 pacientai <a aria-label=\"neapibr\u0117\u017etas (atsidaro naujame skirtuke)\" href=\"https:\/\/www.who.int\/cancer\/palliative\/definition\/en\/\" target=\"_blank\" rel=\"noreferrer noopener\">paliatyvioji prie\u017ei\u016bra<\/a> negali b\u016bti suteikta.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0160tai kod\u0117l mokslininkams taip svarbu diegti naujoves, kad psichodelikos tyrimai <em>(arba apskritai medicininiai tyrimai)<\/em> stengtis, kad \u0161i\u0173 pacient\u0173 patirtys b\u016bt\u0173 lengviau pakeliamos.  Paprasti dalykai, pavyzd\u017eiui, laukimo laiko sutrumpinimas, gali sutaupyti brangi\u0173 paciento kasdien\u0117s rutinos sekund\u017ei\u0173, kurios tur\u0117t\u0173 b\u016bti praleistos patogiai.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0160i nauja psilocibino juosteli\u0173 technologija yra dar vienas \u017eingsnis link psichodelinio gydymo teis\u0117tumo ir veiksmingumo... tai vaidins svarb\u0173 vaidmen\u012f ateities medicinoje, ypa\u010d slaugant pacientus gyvenimo pabaigoje.&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Psichodelik\u0173 pa\u017eadas su kiekvienu mokslini\u0173 tyrim\u0173 laim\u0117jimu tampa vis ry\u0161kesnis. Pavyzd\u017eiui, MDMA terapija pacientams, sergantiems potrauminio streso sutrikimu, arba psilocibino mikrodozavimas kovojant su depresija ir nerimu. O ar pamenate, kai Kanada leido psilocibin\u0105 vartoti gyvenimo pabaigoje?\u00a0<\/p>","protected":false},"author":1,"featured_media":14865,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[],"topics":[],"class_list":["post-14862","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-culture"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/posts\/14862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/comments?post=14862"}],"version-history":[{"count":1,"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/posts\/14862\/revisions"}],"predecessor-version":[{"id":123816,"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/posts\/14862\/revisions\/123816"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/media\/14865"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/media?parent=14862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/categories?post=14862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/tags?post=14862"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lt\/wp-json\/wp\/v2\/topics?post=14862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}