{"id":13908,"date":"2020-07-23T15:36:18","date_gmt":"2020-07-23T15:36:18","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=13908"},"modified":"2023-05-11T17:56:08","modified_gmt":"2023-05-11T15:56:08","slug":"why-the-entourage-effect-matters","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/lv\/blog\/kapec-entures-efekts-ir-nozimigs\/","title":{"rendered":"K\u0101p\u0113c ir svar\u012bgs \"Entourage\" efekts"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-what-is-the-entourage-effect\"><em>Kas ir entourage efekts?<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Jauni p\u0113t\u012bjumi liecina, ka ma\u0123iskaj\u0101s s\u0113n\u0113s ir daudz vair\u0101k efekt\u012bvu savienojumu nek\u0101 tikai psilocib\u012bns. Turkl\u0101t ir \u013coti iesp\u0113jams, ka tiem ir b\u016btiska noz\u012bme s\u0113\u0146u psihed\u0113lisk\u0101s iedarb\u012bbas nodro\u0161in\u0101\u0161an\u0101. To d\u0113v\u0113 par \"pavado\u0161o efektu\". Ir pla\u0161i atz\u012bts, ka tas past\u0101v ar <a aria-label=\"nenoteikts (atveras jaun\u0101 ciln\u0113)\" href=\"https:\/\/www.leafly.com\/news\/cannabis-101\/cannabis-entourage-effect-why-thc-and-cbd-only-medicines-arent-g\" target=\"_blank\" rel=\"noreferrer noopener\">ka\u0146epes<\/a>. Agr\u0101kos p\u0113t\u012bjumos par ka\u0146epju \u012bpa\u0161\u012bb\u0101m uzman\u012bba tika piev\u0113rsta tikai THC.  Tom\u0113r dr\u012bz vien p\u0113t\u012bjumos atkl\u0101j\u0101s, ka tas ir vesels savienojumu kopums, kas kop\u0101 veido t\u0101 iedarb\u012bbu. Tagad ir vienpr\u0101t\u012bba, ka CBD un citi savienojumi ir \u013coti svar\u012bgi, lai ka\u0146epes piln\u012bb\u0101 izmantotu savu potenci\u0101lu. Interesanti, ka attiec\u012bb\u0101 uz burvju s\u0113n\u0113m m\u0113s to tikai tagad atkl\u0101jam. \u0160\u0137iet, ka psihoakt\u012bvajiem savienojumiem pat\u012bk darboties band\u0101s. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-twin-troublemakers\"><em>Dv\u012b\u0146u probl\u0113mu rad\u012bt\u0101ji<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">T\u0101tad, <a aria-label=\"nenoteikts (atveras jaun\u0101 ciln\u0113)\" href=\"https:\/\/staging.wholecelium.com\/lv\/wiki\/mikologija-2\/kas-ir-psilocibins-2\/\" target=\"_blank\" rel=\"noreferrer noopener\">psilocib\u012bns<\/a> ir savienojums, kas parasti piesaista visliel\u0101ko uzman\u012bbu. Atkar\u012bb\u0101 no sugas burvju s\u0113nes sausn\u0101 satur no 0,2 l\u012bdz 1,81 %2T psilocib\u012bna. P\u0113c lieto\u0161anas psilocib\u012bns \u0101tri p\u0101rv\u0113r\u0161as par akt\u012bvo metabol\u012btu psiloc\u012bnu. Gan psilocib\u012bns, gan psiloc\u012bns saist\u0101s ar seroton\u012bna receptoriem. T\u0101tad \u0161ie dv\u012b\u0146u trauc\u0113k\u013ci ir atbild\u012bgi par liel\u0101ko da\u013cu burvju s\u0113\u0146u psihed\u0113lisk\u0101 efekta.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-don-t-underestimate-baeocystin\"><em>Nenov\u0113rt\u0113jiet Baeocystin!<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Psiloci\u012bns veido aptuveni 0,02-0,6% no burvju s\u0113\u0146u sausnas svara atkar\u012bb\u0101 no sugas. N\u0101kam\u0101 visbie\u017e\u0101k sastopam\u0101 molekula ir v\u0113l maz\u0101k zin\u0101mais baeocist\u012bns, tom\u0113r pa\u0161laik par to m\u0113s neko daudz nezin\u0101m. T\u0101pat k\u0101 psiloc\u012bns, tas ir v\u0113l viens psilocib\u012bna atvasin\u0101jums, t\u0101p\u0113c ar\u012b tam, visticam\u0101k, ir k\u0101ds psihoakt\u012bvs rezult\u0101ts. Zin\u0101tnieks Jochens Gartzs aprakst\u012bja, k\u0101 neliela 4 mg deva vi\u0146am sniedza <em>\"maiga halucinog\u0113na pieredze\".<\/em> <em> <\/em>B\u0113ocist\u012bna saturs \u017e\u0101v\u0113t\u0101s burvju s\u0113n\u0113s atkar\u012bb\u0101 no sugas ir aptuveni 0,005-0,36%.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-enter-the-beta-carbolines\"><em>Ievadiet beta-karbol\u012bnus!<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Nesen tika atkl\u0101ts, ka beta-karbol\u012bni ir ar\u012b burvju s\u0113n\u0113s. Beta-karbol\u012bni ir alkalo\u012bdu grupa, kas sastopama daudzos augu veidos. \u012apa\u0161i noz\u012bm\u012bgi ir augu izcelsmes z\u0101l\u0113s <a aria-label=\"nenoteikts (atveras jaun\u0101 ciln\u0113)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Ayahuasca\" target=\"_blank\" rel=\"noreferrer noopener\">ayahuasca<\/a> ietver beta-karbol\u012bnus<em> harm\u012bns, harmal\u012bns<\/em>, un <em>tetrahidroharm\u012bns<\/em>. Tie kav\u0113 monoam\u012bnoksid\u0101zes (MAO) enz\u012bmu, kas atrodas m\u016bsu ku\u0146\u0123\u012b. Ajahuaskas pagatavo\u0161anas sast\u0101v\u0101 ir psihed\u0113lisk\u0101 molekula <a aria-label=\"nenoteikts (atveras jaun\u0101 ciln\u0113)\" href=\"https:\/\/en.wikipedia.org\/wiki\/N,N-Dimethyltryptamine\" target=\"_blank\" rel=\"noreferrer noopener\">DMT<\/a>, ko parasti no\u0101rda enz\u012bms MAO. Tagad j\u016bs varat redz\u0113t, k\u0101 beta-karbol\u012bni s\u0101k darboties; tie blo\u0137\u0113 MAO un pal\u012bdz DMT ilg\u0101k izdz\u012bvot organism\u0101, kur tam var b\u016bt psihoakt\u012bva ietekme.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nesen beta-karbol\u012bni <em>harm\u0101ns, harm\u012bns, harm\u012bns, norharm\u0101ns<\/em> un <em>perlolyrine<\/em> tika konstat\u0113tas \u010detr\u0101m s\u0113\u0146u sug\u0101m. T\u0101pat k\u0101 DMT ayahuask\u0101, ar\u012b psiloc\u012bnu organism\u0101 no\u0101rda enz\u012bms MAO. Tom\u0113r tagad, kad m\u0113s zin\u0101m par beta-karbol\u012bnu esam\u012bbu burvju s\u0113n\u0113s, m\u0113s varam secin\u0101t, ka tie blo\u0137\u0113 MAO enz\u012bmu! Tas pagarina un pastiprina psilocib\u012bna\/psiloc\u012bna iedarb\u012bbu, ne\u013caujot tam sadal\u012bties. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-shrooms-and-ayahuasca-more-similar-than-we-thought\"><em>S\u0113nes un ajahuaska - l\u012bdz\u012bg\u0101kas, nek\u0101 m\u0113s dom\u0101j\u0101m! <\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Interesanti, ka atkl\u0101jums, ka burvju s\u0113nes satur ar\u012b beta-karbol\u012bnus, var\u0113tu noz\u012bm\u0113t, ka ayahuasca un burvju s\u0113nes ir sal\u012bdzin\u0101m\u0101kas, nek\u0101 m\u0113s dom\u0101j\u0101m! Tom\u0113r, vai burvju s\u0113n\u0113s ir pietiekami daudz beta-karbol\u012bnu, lai tie b\u016btiski ietekm\u0113tu lietot\u0101ja pieredzi? No burvju s\u0113\u0146u sug\u0101s konstat\u0113tajiem beta-karbol\u012bniem visbag\u0101t\u0101kais bija beta-karbol\u012bni. <em>harmane<\/em>, kas bija 0,2-21 ug\/g \u017e\u0101v\u0113tas masas. Ajahuaskas nov\u0101r\u012bjumos beta-karbol\u012bni ir akt\u012bvi jau 0,5 mikrogramu koncentr\u0101cij\u0101 vid\u0113jam cilv\u0113kam. Tas liecina, ka m\u0113rena burvju s\u0113nes deva <em>(apm\u0113ram 2 grami \u017e\u0101v\u0113tu s\u0113\u0146u)<\/em> b\u016btu pietiekami daudz, lai \u0161ie beta-karbol\u012bni var\u0113tu veicin\u0101t ce\u013cojumu.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-two-studies-stand-out\"><em>Divi p\u0113t\u012bjumi izce\u013cas<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">T\u0101 k\u0101 liel\u0101k\u0101 da\u013ca kl\u012bnisko p\u0113t\u012bjumu par burvju s\u0113n\u0113m ir koncentr\u0113ju\u0161ies tikai uz psilocib\u012bnu, nav daudz inform\u0101cijas, kas sal\u012bdzina psilocib\u012bna subjekt\u012bvos rezult\u0101tus ar vesel\u0101m s\u0113n\u0113m. Tom\u0113r ir divi p\u0113t\u012bjumi ar dz\u012bvniekiem, kuros ieg\u016bti atbilsto\u0161i rezult\u0101ti. P\u0113t\u012bjum\u0101, kas veikts 2009. gad\u0101, pel\u0113m tika dots vai nu t\u012brs psilocib\u012bns, vai burvju s\u0113\u0146u ekstrakts. Rezult\u0101ti par\u0101d\u012bja, ka burvju s\u0113\u0146u ekstrakts efekt\u012bv\u0101k mazin\u0101ja pe\u013cu nervozit\u0101ti nek\u0101 t\u012brs psilocib\u012bns.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cit\u0101 2015. gad\u0101 veikt\u0101 p\u0113t\u012bjum\u0101 tika konstat\u0113ts, ka burvju s\u0113\u0146u ekstrakts aptuveni 10 reizes efekt\u012bv\u0101k maina trauksmes uzved\u012bbu pel\u0113m, sal\u012bdzinot ar t\u012bru psiloc\u012bnu. \u0160\u0137iet, ka tas apstiprina to, ko p\u0113tnieki izvirz\u012bja hipot\u0113zi, kad atkl\u0101ja beta-karbol\u012bnus burvju s\u0113\u0146u veidos - ka burvju s\u0113\u0146u efektivit\u0101tes atsl\u0113ga var\u0113tu b\u016bt entourage efekts. B\u016bt\u012bb\u0101, k\u0101 skol\u0101 m\u0101c\u012bja, komandas darbs parasti dod lab\u0101ku rezult\u0101tu.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-strengths-may-vary\"><em> Stipr\u0101s puses var at\u0161\u0137irties<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Turkl\u0101t nesen tika konstat\u0113ts, ka da\u017e\u0101d\u0101s vienas un t\u0101s pa\u0161as s\u0113nes da\u013c\u0101s var b\u016bt at\u0161\u0137ir\u012bgs psihoakt\u012bvo vielu daudzums. Da\u017eu sugu s\u0113\u0146u cepur\u012bt\u0113s var b\u016bt divreiz vair\u0101k psilocib\u012bna nek\u0101 k\u0101ti\u0146os! T\u0101pat ar\u012b ma\u0123isk\u0101s trifeles satur at\u0161\u0137ir\u012bgu psilocib\u012bna daudzumu sal\u012bdzin\u0101jum\u0101 ar burvju s\u0113n\u0113m.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-so-what-does-this-mean\"><em>Ko tas noz\u012bm\u0113?<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ko tas noz\u012bm\u0113 m\u016bsu izpratnei par ma\u0123isko s\u0113\u0146u pieredzi? Kopum\u0101 gandr\u012bz visos medic\u012bniskajos p\u0113t\u012bjumos ar cilv\u0113kiem par burvju s\u0113\u0146u terapeitisko potenci\u0101lu ir izmantots izol\u0113ts psilocib\u012bns vai psiloc\u012bns, nevis visas s\u0113nes ekstrakts.<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-why-the-entourage-effect-matters\"><em>K\u0101p\u0113c ir svar\u012bgs \"Entourage\" efekts<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tom\u0113r \u0161\u012b jaun\u0101 interese par enturage efektu, visticam\u0101k, pieaugs. Iesp\u0113jams, n\u0101kotn\u0113, kad psihed\u0113liskie \u0101rst\u0113\u0161anas l\u012bdzek\u013ci b\u016bs ierasta par\u0101d\u012bba, at\u0161\u0137ir\u012bba starp to, vai pat\u0113r\u0113t\u0101ji izv\u0113l\u0113sies farm\u0101cijas uz\u0146\u0113muma izol\u0113ta psilocib\u012bna uztura bag\u0101tin\u0101t\u0101ju vai \u012bsta \u0161\u016bbja vai trifeles mikrodazu, b\u016bs atkar\u012bga no t\u0101diem aspektiem k\u0101 entourage efekts. Tie\u0161i t\u0101p\u0113c ir svar\u012bgs pavado\u0161ais efekts. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-real-vs-synthetic\"><em>Re\u0101ls pret sint\u0113tisku<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">T\u0101p\u0113c, lasot p\u0113t\u012bjumu par sint\u0113tisko psilocib\u012bnu vai psiloc\u012bnu, ir labi patur\u0113t pr\u0101t\u0101 \u0161o at\u0161\u0137ir\u012bbu. Un n\u0101kamreiz, kad nobaud\u012bsiet s\u0113n\u012btes vai trifeles, atcerieties nov\u0113rt\u0113t to savienojumu harmoniju, kas sadarbojas, lai rad\u012btu j\u016bsu pieredzi!<\/p>","protected":false},"excerpt":{"rendered":"<p>Run\u0101jot par burvju s\u0113n\u0113m un to izmanto\u0161anas p\u0113t\u012bjumiem, galven\u0101 uzman\u012bba bie\u017ei tiek piev\u0113rsta psilocib\u012bna da\u013ci\u0146ai. Psilocib\u012bns ir visizplat\u012bt\u0101k\u0101 psihed\u0113lisk\u0101 sast\u0101vda\u013ca s\u0113n\u0113s un burvju trifel\u0113s. Pa\u0161laik p\u0113t\u012bjumos par burvju s\u0113\u0146u labv\u0113l\u012bgo ietekmi bie\u017ei vien izmanto tikai \u0161o savienojumu, nevis visu s\u0113ni kopum\u0101. T\u0101tad, k\u0101p\u0113c visa s\u0113ne ir lab\u0101ka? Ir pien\u0101cis laiks uzzin\u0101t, k\u0101p\u0113c ir svar\u012bgs kompleksa efekts.<\/p>","protected":false},"author":1,"featured_media":13913,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-13908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/13908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/comments?post=13908"}],"version-history":[{"count":1,"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/13908\/revisions"}],"predecessor-version":[{"id":123871,"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/13908\/revisions\/123871"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/media\/13913"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/media?parent=13908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/categories?post=13908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/tags?post=13908"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/lv\/wp-json\/wp\/v2\/topics?post=13908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}