{"id":13908,"date":"2020-07-23T15:36:18","date_gmt":"2020-07-23T15:36:18","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=13908"},"modified":"2023-05-11T17:56:08","modified_gmt":"2023-05-11T15:56:08","slug":"why-the-entourage-effect-matters","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/ro\/blog\/de-ce-conteaza-efectul-de-entuziasm\/","title":{"rendered":"De ce conteaz\u0103 efectul Entourage"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-what-is-the-entourage-effect\"><em>Ce este efectul Entourage?<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Noile cercet\u0103ri au ar\u0103tat c\u0103 \u00een ciupercile magice exist\u0103 mult mai mul\u021bi compu\u0219i eficien\u021bi dec\u00e2t psilocibina. \u00cen plus, este foarte probabil ca ace\u0219tia s\u0103 joace un rol vital \u00een efectele psihedelice ale ciupercilor. Acest lucru este cunoscut sub numele de \"efect de anturaj\". Este recunoscut pe scar\u0103 larg\u0103 c\u0103 exist\u0103 cu <a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/www.leafly.com\/news\/cannabis-101\/cannabis-entourage-effect-why-thc-and-cbd-only-medicines-arent-g\" target=\"_blank\" rel=\"noreferrer noopener\">canabis<\/a>. Cercet\u0103rile anterioare privind propriet\u0103\u021bile canabisului se concentrau exclusiv pe THC.  Cur\u00e2nd, \u00eens\u0103, studiile au descoperit c\u0103 o \u00eentreag\u0103 constela\u021bie de compu\u0219i se combin\u0103 pentru a crea efectul s\u0103u. \u00cen prezent, s-a convenit c\u0103 CBD, printre al\u021bi compu\u0219i, este vital pentru ca canabisul s\u0103-\u0219i ating\u0103 poten\u021bialul maxim. Interesant, este un lucru pe care abia acum \u00eel descoperim c\u00e2nd vine vorba de ciupercile magice. Se pare c\u0103 compu\u0219ilor psihoactivi le place s\u0103 stea \u00een g\u0103\u0219ti. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-twin-troublemakers\"><em>Probleme gemene<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Deci, <a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/staging.wholecelium.com\/ro\/wiki\/micologie-2\/ce-este-psilocybin-2\/\" target=\"_blank\" rel=\"noreferrer noopener\">psilocibin\u0103<\/a> este compusul care atrage de obicei cea mai mare aten\u021bie. Ciupercile magice con\u021bin \u00eentre 0,2-1,8% psilocibin\u0103 \u00een greutate uscat\u0103, \u00een func\u021bie de specie. Odat\u0103 consumat\u0103, psilocibina se transform\u0103 rapid \u00een metabolitul s\u0103u activ, psilocina. At\u00e2t psilocibina, c\u00e2t \u0219i psilocina se leag\u0103 de receptorii de serotonin\u0103. A\u0219adar, ace\u0219ti doi perturbatori gemeni sunt responsabili pentru majoritatea efectelor psihedelice ale ciupercilor magice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-don-t-underestimate-baeocystin\"><em>Nu subestima\u021bi Baeocystin!<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Psilocyin reprezint\u0103 aproximativ 0,02-0,6% din greutatea uscat\u0103 a ciupercilor magice, \u00een func\u021bie de specie. Apoi, baeocistina, chiar mai pu\u021bin cunoscut\u0103, este urm\u0103toarea molecul\u0103 cea mai abundent\u0103 - cu toate acestea, \u00een prezent nu \u00een\u021belegem prea multe despre ea. Ca \u0219i psilocina, este un alt derivat al psilocibinei, deci este probabil s\u0103 aib\u0103 \u0219i ea un fel de rezultat psihoactiv. Omul de \u0219tiin\u021b\u0103 Jochen Gartz a descris modul \u00een care o doz\u0103 mic\u0103 de 4 mg i-a furnizat <em>\"o experien\u021b\u0103 halucinogen\u0103 delicat\u0103\".<\/em> <em> <\/em>Baeocistina este prezent\u0103 la o concentra\u021bie de aproximativ 0,005-0,36% \u00een ciupercile magice uscate, \u00een func\u021bie de specie.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-enter-the-beta-carbolines\"><em>Introduce\u021bi Beta-Carbolinele!<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Prezen\u021ba beta-carbolinelor a fost, de asemenea, descoperit\u0103 recent \u00een ciupercile magice. Beta-carbolinele sunt o clas\u0103 de alcaloizi care se g\u0103sesc \u00een multe tipuri de plante. \u00cen special, planta medicinal\u0103 <a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Ayahuasca\" target=\"_blank\" rel=\"noreferrer noopener\">ayahuasca<\/a> include beta-carbolinele<em> harmin\u0103, harmalin\u0103<\/em>, \u0219i <em>tetrahidroharmin\u0103<\/em>. Acestea obstruc\u021bioneaz\u0103 enzima monoaminooxidaz\u0103 (MAO) care exist\u0103 \u00een stomacul nostru. B\u0103uturile de ayahuasca includ molecula psihedelic\u0103 <a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/en.wikipedia.org\/wiki\/N,N-Dimethyltryptamine\" target=\"_blank\" rel=\"noreferrer noopener\">DMT<\/a>, care \u00een mod normal este descompus\u0103 de enzima MAO. Pute\u021bi vedea acum cum intr\u0103 \u00een joc beta-carbolinele; acestea blocheaz\u0103 MAO \u0219i ajut\u0103 DMT-ul s\u0103 supravie\u021buiasc\u0103 mai mult timp \u00een organism, unde poate avea un impact psihoactiv.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Recent, beta-carbolinele <em>harman\u0103, harmin\u0103, norharman\u0103<\/em> \u0219i <em>perlolyrine<\/em> au fost g\u0103site la patru specii de ciuperci. La fel ca DMT din ayahuasca, psilocina este, de asemenea, descompus\u0103 \u00een organism de c\u0103tre enzima MAO. Cu toate acestea, acum c\u0103 \u0219tim de existen\u021ba beta-carbolinelor \u00een ciupercile magice, putem deduce c\u0103 acestea blocheaz\u0103 enzima MAO! Acest lucru prelunge\u0219te \u0219i amplific\u0103 experien\u021ba psilocibinei\/psilocinei, \u00eempiedic\u00e2nd descompunerea acesteia. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-shrooms-and-ayahuasca-more-similar-than-we-thought\"><em>Ciupercile \u0219i Ayahuasca - mai asem\u0103n\u0103toare dec\u00e2t am crezut! <\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen mod fascinant, descoperirea c\u0103 ciupercile magice includ \u0219i beta-carboline ar putea \u00eensemna c\u0103 ayahuasca \u0219i ciupercile magice sunt mai comparabile dec\u00e2t am crezut! Cu toate acestea, exist\u0103 suficiente beta-carboline \u00een ciupercile magice pentru a avea un efect semnificativ asupra experien\u021bei utilizatorului? Ei bine, cea mai abundent\u0103 dintre beta-carbolinele g\u0103site \u00een speciile de ciuperci magice a fost <em>harmane<\/em>, care s-a dovedit a fi \u00eentre 0,2-21 ug\/g de mas\u0103 uscat\u0103. \u00cen infuziile de ayahuasca, beta-carbolinele sunt active la niveluri de p\u00e2n\u0103 la 0,5 micrograme pentru o persoan\u0103 obi\u0219nuit\u0103. Acest lucru sugereaz\u0103 c\u0103 o doz\u0103 moderat\u0103 de ciuperci magice <em>(aproximativ 2 grame de ciuperci uscate)<\/em> ar fi suficient pentru ca aceste beta-carboline s\u0103 contribuie la c\u0103l\u0103torie.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-two-studies-stand-out\"><em>Dou\u0103 studii ies \u00een eviden\u021b\u0103<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Deoarece majoritatea cercet\u0103rilor clinice privind ciupercile magice s-au concentrat \u00een \u00eentregime pe psilocibin\u0103, nu exist\u0103 prea multe informa\u021bii care s\u0103 compare rezultatele subiective ale psilocibinei \u00een compara\u021bie cu ciupercile \u00eentregi. Cu toate acestea, exist\u0103 dou\u0103 studii pe animale cu rezultate pertinente. \u00centr-un studiu din 2009, \u0219oarecilor li s-a administrat fie psilocibin\u0103 pur\u0103, fie extract de ciuperci magice. Rezultatele au ar\u0103tat c\u0103 extractul de ciuperci magice a fost mai eficient \u00een reducerea comportamentelor nervoase la \u0219oareci dec\u00e2t psilocibina pur\u0103.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Un alt studiu, din 2015, a constatat c\u0103 extractul de ciuperci magice a fost de aproximativ 10 ori mai eficient \u00een modificarea ac\u021biunilor comportamentale anxioase la \u0219oareci, \u00een compara\u021bie cu psilocina pur\u0103. Acest lucru pare s\u0103 confirme ceea ce au presupus cercet\u0103torii atunci c\u00e2nd au descoperit beta-carboline \u00een tipurile de ciuperci magice - c\u0103 efectul de anturaj din ciupercile magice poate fi cheia eficien\u021bei lor. Practic, a\u0219a cum v-au \u00eenv\u0103\u021bat la \u0219coal\u0103, munca \u00een echip\u0103 produce, de obicei, un rezultat mai bun.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-strengths-may-vary\"><em> Punctele forte pot varia<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen plus, s-a descoperit recent c\u0103 diferite p\u0103r\u021bi ale aceleia\u0219i ciuperci pot con\u021bine cantit\u0103\u021bi diferite de substan\u021be psihoactive. La unele specii, p\u0103l\u0103riile pot include de dou\u0103 ori mai mult\u0103 psilocibin\u0103 dec\u00e2t tulpinile! \u00cen mod similar, trufele magice con\u021bin cantit\u0103\u021bi diferite de psilocibin\u0103 \u00een compara\u021bie cu ciupercile magice.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-so-what-does-this-mean\"><em>Deci, ce \u00eenseamn\u0103 acest lucru?<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Deci, ce \u00eenseamn\u0103 acest lucru pentru \u00een\u021belegerea noastr\u0103 a experien\u021bei ciupercii magice? \u00cen general, aproape toate cercet\u0103rile medicale efectuate pe oameni cu privire la poten\u021bialul terapeutic al ciupercilor magice au utilizat psilocibin\u0103 sau psilocin\u0103 izolat\u0103, mai degrab\u0103 dec\u00e2t extractul din \u00eentreaga ciuperc\u0103.<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-why-the-entourage-effect-matters\"><em>De ce conteaz\u0103 efectul Entourage<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Cu toate acestea, acest nou interes pentru efectul de anturaj va cre\u0219te probabil. Poate c\u0103, \u00een viitor, c\u00e2nd tratamentele psihedelice vor fi ceva obi\u0219nuit, diferen\u021ba dintre consumatorii care aleg un supliment de psilocibin\u0103 izolat\u0103 de o companie farmaceutic\u0103 sau o microdoz\u0103 de ciuperci sau trufe reale se va reduce la aspecte precum efectul de anturaj. Iat\u0103 de ce conteaz\u0103 efectul de anturaj. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-real-vs-synthetic\"><em>Real vs. sintetic<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A\u0219adar, atunci c\u00e2nd citi\u021bi un studiu de cercetare despre psilocibina sintetic\u0103 sau psilocina, este bine s\u0103 \u021bine\u021bi cont de aceast\u0103 diferen\u021b\u0103. Iar data viitoare c\u00e2nd v\u0103 ve\u021bi droga cu ciuperci sau trufe, nu uita\u021bi s\u0103 aprecia\u021bi armonia compu\u0219ilor, care lucreaz\u0103 \u00eempreun\u0103 pentru a v\u0103 crea experien\u021ba!<\/p>","protected":false},"excerpt":{"rendered":"<p>C\u00e2nd vine vorba de ciupercile magice \u0219i de cercet\u0103rile privind utiliz\u0103rile acestora, particula psilocibin\u0103 este cea care se afl\u0103 adesea \u00een centrul aten\u021biei. Psilocibina este cea mai abundent\u0103 component\u0103 psihedelic\u0103 din ciuperci \u0219i trufe magice. \u00cen prezent, cercet\u0103rile privind beneficiile ciupercilor magice utilizeaz\u0103 adesea doar acest compus, \u00een loc de \u00eentreaga ciuperc\u0103. Deci, de ce este mai bun\u0103 \u00eentreaga ciuperc\u0103? Este timpul s\u0103 afl\u0103m de ce conteaz\u0103 efectul de anturaj.<\/p>","protected":false},"author":1,"featured_media":13913,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-13908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/13908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/comments?post=13908"}],"version-history":[{"count":1,"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/13908\/revisions"}],"predecessor-version":[{"id":123871,"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/13908\/revisions\/123871"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/media\/13913"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/media?parent=13908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/categories?post=13908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/tags?post=13908"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/ro\/wp-json\/wp\/v2\/topics?post=13908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}