{"id":113751,"date":"2023-03-16T16:47:15","date_gmt":"2023-03-16T15:47:15","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=113751"},"modified":"2023-05-04T11:42:36","modified_gmt":"2023-05-04T09:42:36","slug":"can-psilocybin-treat-chronic-pain-in-veterans","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/sk\/blog\/can-psilocybin-treat-chronic-pain-in-veterans\/","title":{"rendered":"M\u00f4\u017ee psilocyb\u00edn lie\u010di\u0165 chronick\u00fa boles\u0165 u veter\u00e1nov?"},"content":{"rendered":"

\u00a0<\/strong><\/p>\n\n\n\n

Veter\u00e1ni sa st\u00e1vaj\u00fa objektmi psychedelick\u00e9ho v\u00fdskumu<\/h2>\n\n\n\n

Kv\u00f4li t\u00fdmto probl\u00e9mom s\u00fa veter\u00e1ni najviac ohrozen\u00ed dvojitou hrozbou z\u00e1vislosti od opi\u00e1tov a smrti z pred\u00e1vkovania. V\u010faka tomu v\u0161ak maj\u00fa aj jedine\u010dn\u00e9 postavenie na \u010dele v\u00fdskumu, ktor\u00fd ukazuje, \u017ee psychedelik\u00e1 m\u00f4\u017eu by\u0165 sp\u00f4sobom \u00fa\u010dinnej\u0161ej lie\u010dby chronickej bolesti. A na rozdiel od opioidov bez rizika pred\u00e1vkovania alebo z\u00e1vislosti. <\/p>\n\n\n\n

\"\"
Foto: Filip Andrejevic on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Psychedelick\u00e1 renesancia v poslednom desa\u0165ro\u010d\u00ed narast\u00e1 a Nemocnice VA<\/a> v USA sa stali prekvapiv\u00fdm epicentrom kontrolovan\u00fdch psychedelick\u00fdch pokusov. V r\u00e1mci t\u00fdchto pokusov sa psychedelik\u00e1, ako napr\u00edklad psilocyb\u00edn z magick\u00fdch h\u00fab, pou\u017e\u00edvali na lie\u010dbu ochoren\u00ed, ako napr. PTSD<\/a>, depresie a \u00fazkosti. D\u00f4vody s\u00fa dvojak\u00e9: po prv\u00e9 preto, \u017ee veter\u00e1ni s\u00fa n\u00e1chylnej\u0161\u00ed trpie\u0165 t\u00fdmito stavmi. A po druh\u00e9 preto, \u017ee nemocnice VA s\u00fa kontrolovan\u00fdm prostred\u00edm, ktor\u00e9 je ide\u00e1lne na vykon\u00e1vanie t\u00fdchto typov sk\u00fa\u0161ok. <\/p>\n\n\n\n

V\u010faka t\u00fdmto \u0161t\u00fadi\u00e1m u\u017e existuj\u00fa presved\u010div\u00e9 predbe\u017en\u00e9 \u00fadaje o \u00fa\u010dinnosti a bezpe\u010dnosti pou\u017e\u00edvania psychedel\u00edk na lie\u010dbu du\u0161evn\u00e9ho zdravia a psychiatrick\u00fdch probl\u00e9mov, ako s\u00fa posttraumatick\u00e1 stresov\u00e1 porucha, depresia, \u00fazkos\u0165 a z\u00e1vislosti od n\u00e1vykov\u00fdch l\u00e1tok. <\/p>\n\n\n\n

Pou\u017e\u00edvanie psychedel\u00edk na lie\u010dbu fyzickej bolesti<\/h2>\n\n\n\n

Pokia\u013e v\u0161ak ide o pou\u017e\u00edvanie psychedel\u00edk na lie\u010dbu chronickej bolesti, v\u00fdskumov je zatia\u013e menej. A hoci v\u00fdskum, ktor\u00fd sa v s\u00fa\u010dasnosti objavuje, je s\u013eubn\u00fd, st\u00e1le je len v po\u010diato\u010dnom \u0161t\u00e1diu. To je v\u0161ak nie prv\u00fdkr\u00e1t<\/a> bol navrhnut\u00fd v\u00fdskum pou\u017e\u00edvania psychedel\u00edk pri fyzickej bolesti. Vzh\u013eadom na mno\u017estvo \u0161t\u00fadi\u00ed sa ur\u010dite \u010doskoro dozvieme ove\u013ea viac. <\/p>\n\n\n\n

Existuje aj mnoho \u013eud\u00ed, ktor\u00ed sa radi podelia o svoje pr\u00edbehy o tom, ako psychedelik\u00e1 lie\u010dili chronick\u00fa boles\u0165 alebo im pomohli vyrovna\u0165 sa s \u0148ou: <\/strong><\/p>\n\n\n\n

Jedn\u00fdm z nich je Jose Martines, veter\u00e1n, ktor\u00e9ho profil uverejnil denn\u00edk New York Times v roku 2021. Po zranen\u00ed podst\u00fapil 19 oper\u00e1ci\u00ed a st\u00e1le mal extr\u00e9mne bolesti. To sp\u00f4sobilo, \u017ee bol z\u00e1visl\u00fd od opi\u00e1tov. Vysk\u00fa\u0161al v\u0161ak psilocyb\u00edn, ktor\u00fd mu, na\u0161\u0165astie, zmenil \u017eivot. Martinez to vysvetlil denn\u00edku New York Times; <\/p>\n\n\n\n

\"Psychedelik\u00e1 mi pomohli uvedomi\u0165 si, \u017ee moje probl\u00e9my s\u00fa mal\u00e9 v porovnan\u00ed s v\u00e4\u010d\u0161\u00edmi probl\u00e9mami sveta, ako je hlad a rakovina... Teraz ch\u00e1pem, na \u010do som vlastne na tomto svete, a to, aby som \u013eud\u00ed rozosmieval a pripom\u00ednal im, \u017ee \u017eivot m\u00f4\u017ee by\u0165 kr\u00e1sny, aj ke\u010f nie je tak\u00fd jednoduch\u00fd.\"<\/em><\/p>\n\n\n\n

\"\"
cez Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Hoci st\u00e1le trp\u00ed ur\u010dit\u00fdmi boles\u0165ami, jeho poh\u013ead sa zmenil. Okrem toho, \u017ee je hlasn\u00fdm z\u00e1stancom psychedel\u00edk, pomohol spusti\u0165 Iniciat\u00edvu pre v\u00fdskum psychedel\u00edk a zdravia na Kalifornskej univerzite v San Diegu (PHRI<\/a>)<\/em>, je tie\u017e paralympijsk\u00fdm surferom a \u0161portov\u00fdm nad\u0161encom. <\/p>\n\n\n\n

Psilocyb\u00edn pri fant\u00f3movej bolesti kon\u010dat\u00edn?<\/h2>\n\n\n\n

\u010eal\u0161\u00edm tak\u00fdmto pr\u00edbehom je pr\u00edbeh Alberta Yu-Mina Lina, vedca a v\u00fdskumn\u00edka National Geographic. V roku 2016 pri\u0161iel pri nehode v p\u00fa\u0161ti o doln\u00fa \u010das\u0165 nohy. Kr\u00e1tko na to za\u010dal za\u017e\u00edva\u0165 stra\u0161n\u00e9 fant\u00f3mov\u00e1 boles\u0165 kon\u010dat\u00edn<\/a>. U\u017e po jednom psilocyb\u00ednovom seden\u00ed Lin zistil, \u017ee jeho boles\u0165 sa v\u00fdrazne zn\u00ed\u017eila. Hovor\u00ed, \u017ee t\u00e1to sk\u00fasenos\u0165 mu vr\u00e1tila \u017eivot. <\/p>\n\n\n\n

Hist\u00f3ria pou\u017e\u00edvania psychedel\u00edk na lie\u010dbu fyzickej bolesti<\/h2>\n\n\n\n

Ako sme u\u017e spomenuli, v\u00fdskum pou\u017e\u00edvania psychedel\u00edk na lie\u010dbu fyzickej bolesti nie je nov\u00fd. Prv\u00e9 v\u00fdskumy sa datuj\u00fa do roku 1964, ke\u010f anest\u00e9ziol\u00f3g Eric Kast podal 100 mikrogramov LSD 50 \"v\u00e1\u017ene chor\u00fd\" <\/em>pacientov. T\u00edto pacienti trpeli v\u0161etk\u00fdm mo\u017en\u00fdm, od gangr\u00e9ny a\u017e po rakovinu. Potom porovnal ich reakciu na boles\u0165 s dvoma \u010fal\u0161\u00edmi syntetick\u00fdmi opioidmi (Demerol a Dilaudid.) <\/em>Kast zistil, \u017ee \"V porovnan\u00ed s LSD-25 boli obe [ostatn\u00e9] drogy nedostato\u010dn\u00e9 vo svojom analgetickom \u00fa\u010dinku,\" <\/em><\/p>\n\n\n\n

Nane\u0161\u0165astie, kr\u00e1tko na to \"vojna proti drog\u00e1m\" a negat\u00edvny obraz potla\u010dili pokusy o \u0161t\u00fadium psychedel\u00edk v USA a mnoh\u00fdch \u010fal\u0161\u00edch krajin\u00e1ch. To sa na\u0161\u0165astie men\u00ed. <\/p>\n\n\n\n

Najnov\u0161ie \u0161t\u00fadie s\u00fa ved\u00face<\/h2>\n\n\n\n

V roku 2020 sa uskuto\u010dnila dvojito zaslepen\u00e1, placebom kontrolovan\u00e1, randomizovan\u00e1 \u0161t\u00fadium<\/a> uskuto\u010dnenej na holandskej Maastrichtskej univerzite bola publikovan\u00e1 v \u010dasopise Journal of Psychopharmacology. Zamerala sa na psychedelik\u00e1 a fyzick\u00fa boles\u0165. Ke\u010f \u00fa\u010dastn\u00edci dostali LSD, dokonca aj n\u00edzke d\u00e1vky, dok\u00e1zali udr\u017ea\u0165 ruky v takmer mrazivej vode takmer rovnako dlho ako t\u00ed, ktor\u00ed u\u017e\u00edvali opioidy, ako je morfium (na z\u00e1klade \u00fadajov z predch\u00e1dzaj\u00facich \u0161t\u00fadi\u00ed.) <\/em>Autori dospeli k z\u00e1veru, \u017ee v n\u00edzkych d\u00e1vkach LSD m\u00f4\u017ee \"...predstavuj\u00fa nov\u00fa farmakologick\u00fa lie\u010dbu.\"<\/em><\/p>\n\n\n\n

\"\"
Foto: Scott Graham on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

V \u0161t\u00fadii z roku 2021 sa potom zistilo, \u017ee \u013eudia trpiaci chronickou boles\u0165ou vykazovali v\u00fdrazne lep\u0161ie v\u00fdsledky bolesti po\u010das psychedelick\u00fdch z\u00e1\u017eitkov a po nich. \u010eal\u0161ia \u0161t\u00fadia z roku 2021 zistila, \u017ee pri podan\u00ed \u010do i len jednej d\u00e1vky psilocyb\u00ednu osoby trpiace migr\u00e9nou zaznamenali pozoruhodn\u00e9 zn\u00ed\u017eenie pr\u00edznakov migr\u00e9ny. Bolo to v porovnan\u00ed s t\u00fdmi, ktor\u00fdm bolo podan\u00e9 placebo. <\/p>\n\n\n\n

Okrem toho mnoho \u010fal\u0161\u00edch v\u00fdskumn\u00edkov oznamuje podobn\u00e9 pokusy s psychedel\u00edkmi na lie\u010dbu fyzickej bolesti. <\/p>\n\n\n\n

Kalifornsk\u00e1 univerzita v San Franciscu \u010doskoro spust\u00ed \u0161t\u00fadiu, v r\u00e1mci ktorej sa bude sk\u00fama\u0165, \u010di lie\u010dba psilocyb\u00ednom dok\u00e1\u017ee lie\u010di\u0165 bolesti v dolnej \u010dasti chrbta. V\u00fdskumn\u00edci uv\u00e1dzaj\u00fa; \"T\u00e1to \u0161t\u00fadia sk\u00fama \u00fa\u010dinky jednorazovej d\u00e1vky psilocyb\u00ednu v kombin\u00e1cii s terapeutick\u00fdm pr\u00edpravkom a integra\u010dn\u00fdmi \u0161t\u00fadiami... D\u00fafame, \u017ee lie\u010dba psilocyb\u00ednom povedie k zlep\u0161eniu ru\u0161iv\u00fdch \u00fa\u010dinkov bolesti... s\u00favisiacich s chronickou boles\u0165ou chrbta.\"<\/em><\/p>\n\n\n\n

\"\"
Foto: Jonathan Borba on Unsplash<\/em><\/mark><\/figcaption><\/figure>\n\n\n\n

Naliehav\u00e1 potreba psychedelickej alternat\u00edvy <\/h2>\n\n\n\n

Naliehavos\u0165 v\u00fdskumu psychedel\u00edk ako lie\u010dby chronickej bolesti vypl\u00fdva z toho, \u017ee v s\u00fa\u010dasnosti s\u00fa najbe\u017enej\u0161ou lie\u010debnou met\u00f3dou opioidy. V jednej \u0161t\u00fadii sa uv\u00e1dza, \u017ee lek\u00e1ri predp\u00edsali opioidy \u2154 veter\u00e1nov s chronickou boles\u0165ou v priebehu jedn\u00e9ho roka. Hoci je to v poriadku, ak sa opioidy pou\u017e\u00edvaj\u00fa pod\u013ea predpisu, nes\u00fa so sebou zna\u010dn\u00e9 riziko z\u00e1vislosti a pred\u00e1vkovania. A ke\u010f m\u00e1te neust\u00e1le bolesti, je ve\u013emi \u013eahk\u00e9 sta\u0165 sa z\u00e1visl\u00fdm od l\u00e1tky, ktor\u00e1 zab\u00edja boles\u0165. Pod\u013ea CDC<\/a>, opioidy priamo sp\u00f4sobili alebo prispeli k 68 630 \u00famrtiam v USA len v roku 2020. <\/p>\n\n\n\n

U veter\u00e1nov je dvakr\u00e1t vy\u0161\u0161ia pravdepodobnos\u0165 pred\u00e1vkovania drogami ako u ostatnej popul\u00e1cie a tie\u017e ove\u013ea vy\u0161\u0161ia pravdepodobnos\u0165 sp\u00e1chania samovra\u017edy. <\/p>\n\n\n\n

Psychedelik\u00e1 nie s\u00fa n\u00e1vykov\u00e9 a \"prep\u00e1jaj\u00fa\" mozog<\/h2>\n\n\n\n

Na rozdiel od opi\u00e1tov nie s\u00fa psychedelik\u00e1 n\u00e1vykov\u00e9 a je takmer nemo\u017en\u00e9 sa nimi smrte\u013ene pred\u00e1vkova\u0165. V roku 2020 sa v preh\u013eadovom \u010dl\u00e1nku v publik\u00e1cii British Medical Journal uv\u00e1dza;<\/p>\n\n\n\n

\"Psychedelick\u00e9 l\u00e1tky maj\u00fa vo v\u0161eobecnosti priazniv\u00fd bezpe\u010dnostn\u00fd profil, najm\u00e4 v porovnan\u00ed s opioidn\u00fdmi analgetikami.\"<\/em><\/p>\n\n\n\n

Okrem toho psychedelik\u00e1 m\u00f4\u017eu poskytn\u00fa\u0165 dlh\u0161ie trvaj\u00facu \u00fa\u013eavu ako opioidy, ktor\u00e9 \u00fa\u010dinkuj\u00fa len dovtedy, k\u00fdm nevyprchaj\u00fa. A v niektor\u00fdch pr\u00edpadoch, ako je napr\u00edklad syndr\u00f3m fant\u00f3mov\u00fdch kon\u010dat\u00edn, ide o neurologick\u00e9 postihnutie. Potenci\u00e1l psychedel\u00edk reorganizova\u0165 dr\u00e1hy v mozgu.<\/a>, by mohli by\u0165 k\u013e\u00fa\u010dom k dlhodobej\u0161ej lie\u010dbe tak\u00fdchto ochoren\u00ed. <\/p>\n\n\n\n

\"\"
cez Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Predbe\u017en\u00e9 zistenia Iniciat\u00edvy pre v\u00fdskum psychedel\u00edk a zdravia na Kalifornskej univerzite v San Diegu nazna\u010duj\u00fa, \u017ee psychedelik\u00e1 m\u00f4\u017eu v\u00fdrazne a mo\u017eno aj natrvalo zn\u00ed\u017ei\u0165 chronick\u00fa boles\u0165 sp\u00f4soben\u00fa mnoh\u00fdmi r\u00f4znymi stavmi. Patria medzi ne klastrov\u00e9 bolesti hlavy, fant\u00f3mov\u00e9 bolesti kon\u010dat\u00edn, tinnitus a komplexn\u00e1 region\u00e1lna bolestiv\u00e1 porucha. <\/p>\n\n\n\n

Za\u010diatok revol\u00facie v zdravotn\u00edctve?<\/h2>\n\n\n\n

Mohol by to by\u0165 za\u010diatok revol\u00facie v zdravotn\u00edctve. Chronick\u00e1 boles\u0165 je hlavnou pr\u00ed\u010dinou invalidity na celom svete. T\u00ed, ktor\u00ed \u0148ou trpia, by nemali riskova\u0165 z\u00e1vislos\u0165 a pred\u00e1vkovanie len preto, aby si lie\u010dili svoje pr\u00edznaky . Psychedelik\u00e1, ako napr\u00edklad psilocyb\u00edn, m\u00f4\u017eu by\u0165 k\u013e\u00fa\u010dom k uzdraveniu mili\u00f3nov \u013eud\u00ed na celom svete. <\/p>\n\n\n\n

\"\"<\/figure>","protected":false},"excerpt":{"rendered":"

Takmer 50% veter\u00e1nov, ktor\u00ed za\u017eili boj, sa vracia s chronickou boles\u0165ou. Naproti tomu 26% v\u0161eobecnej popul\u00e1cie trp\u00ed chronickou boles\u0165ou, \u010do znamen\u00e1, \u017ee pravdepodobnos\u0165 v\u00fdskytu bolesti u veter\u00e1nov je takmer dvakr\u00e1t vy\u0161\u0161ia. V jednom prieskume sa zistilo, \u017ee pribli\u017ene polovica veter\u00e1nov s chronickou boles\u0165ou trpela aspo\u0148 rok. A z nich viac ako polovica mala bolesti neust\u00e1le alebo aspo\u0148 denne. Viac ako 50% z nich hodnotilo svoju chronick\u00fa boles\u0165 ako siln\u00fa alebo stredne siln\u00fa.<\/p>","protected":false},"author":1,"featured_media":113774,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88],"tags":[],"topics":[],"class_list":["post-113751","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/113751","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/comments?post=113751"}],"version-history":[{"count":1,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/113751\/revisions"}],"predecessor-version":[{"id":122308,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/113751\/revisions\/122308"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/media\/113774"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/media?parent=113751"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/categories?post=113751"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/tags?post=113751"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/topics?post=113751"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}