{"id":14862,"date":"2020-10-17T16:58:00","date_gmt":"2020-10-17T16:58:00","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=14862"},"modified":"2023-05-11T14:16:00","modified_gmt":"2023-05-11T12:16:00","slug":"the-psilocybin-strips-changing-medicine","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/sk\/blog\/the-psilocybin-strips-changing-medicine\/","title":{"rendered":"Psilocyb\u00ednov\u00e9 p\u00e1siky meniace medic\u00ednu"},"content":{"rendered":"<h2 class=\"wp-block-heading\" id=\"h-the-psilocybin-strips-changing-medicine\"><em>Psilocyb\u00ednov\u00e9 p\u00e1siky meniace medic\u00ednu<\/em><\/h2>\n\n\n\n\n\n<p class=\"wp-block-paragraph\">Je tu aj n\u00e1val ve\u013ek\u00fdch, uzn\u00e1van\u00fdch univerz\u00edt, ktor\u00e9 minul\u00fd mesiac otvorili vlastn\u00e9 centr\u00e1 pre v\u00fdskum psychedel\u00edk, konkr\u00e9tne Centrum pre vedu o psychedelik\u00e1ch na Kalifornskej univerzite v Berkeley.<strong>,<\/strong> Otvorenie Johns Hopkins 2019 a NYU Langone Health <a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/cheddar.com\/media\/mindmed-psychedelics-nyu-langone-nasdaq-uplist\" target=\"_blank\" rel=\"noreferrer noopener\">nadch\u00e1dzaj\u00faca div\u00edzia<\/a>, v\u0161etci h\u013eadaj\u00fa \u010fal\u0161\u00ed ve\u013ek\u00fd objav psychedelickej medic\u00edny.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vzru\u0161uj\u00face spr\u00e1vy, v\u0161ak? Po\u010dkajte, k\u00fdm sa dozviete o <a label=\"undefined (opens in a new tab)\" href=\"https:\/\/www.cybin.com\/cybin-corp-and-intelgenx-corp-enter-into-feasibility-agreement-for-fast-acting-orally-dissolving-psilocybin-film\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\"><em>Cybin's <\/em>nov\u00fd drvi\u010d<\/a>: filmov\u00fd p\u00e1s s vysokou d\u00e1vkou psilocyb\u00ednu, ktor\u00fd sa doslova rozpl\u00fdva v \u00fastach... Toto s\u00fa psilocyb\u00ednov\u00e9 p\u00e1siky, ktor\u00e9 menia liek...<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-oral-vs-sublingual-intake-of-psilocybin\"><strong> <\/strong><em>Peror\u00e1lny vs. sublingv\u00e1lny pr\u00edjem psilocyb\u00ednu <\/em><\/h2>\n\n\n\n<figure><img decoding=\"async\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/2020\/10\/mouths-scaled-1.jpg\" alt=\"\" \/><figcaption><mark><em>(S l\u00e1skav\u00fdm dovolen\u00edm: webov\u00e1 str\u00e1nka IntelGenX)<\/em><\/mark><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Spolo\u010dnos\u0165 Cybin Corporation spolupracuje s <a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/www.intelgenx.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">IntelGenx<\/a> <strong>,<\/strong> spolo\u010dnos\u0165 zaoberaj\u00faca sa technol\u00f3giami pre peror\u00e1lne pod\u00e1vanie liekov, aby <em>Psilotonin\u2122<\/em> - v\u00f4bec prv\u00e9 r\u00fdchlorozpustn\u00e9 p\u00e1siky s farmaceutick\u00fdm psilocyb\u00ednom. 25 mg psilocyb\u00ednov\u00e9 filmov\u00e9 pr\u00fa\u017eky s\u00fa ur\u010den\u00e9 na sublingv\u00e1lne <em>(alebo pod jazyk)<\/em> na rozdiel od v\u00e4\u010d\u0161iny klinick\u00fdch \u0161t\u00fadi\u00ed a psychedelick\u00fdch terapi\u00ed, ktor\u00e9 pou\u017e\u00edvaj\u00fa kapsuly.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pri \u0161tandardnom sp\u00f4sobe pod\u00e1vania mus\u00ed psilocyb\u00edn prejs\u0165 tr\u00e1viacim syst\u00e9mom, aby sa mohol premeni\u0165 na psiloc\u00edn - bioakt\u00edvnu zl\u00fa\u010deninu, ktor\u00e1 p\u00f4sob\u00ed na mozog <em><a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\">\"horm\u00f3n \u0161\u0165astia\"<\/a><\/em><strong><a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\"> <\/a><\/strong> receptory.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>(Pozn\u00e1mka na okraj: Preto zvy\u010dajne trv\u00e1 aspo\u0148 30 min\u00fat, k\u00fdm sa cesta uskuto\u010dn\u00ed. Teraz to viete!)<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Je tie\u017e potrebn\u00e9 poznamena\u0165, \u017ee 50-60% d\u00e1vky 25mg sa pri peror\u00e1lnom pod\u00e1van\u00ed strat\u00ed, \u010do znamen\u00e1, \u017ee sa nikdy nedostane do krvn\u00e9ho obehu... alebo sa dostane do mozgu.  Je to preto, \u017ee ve\u013ek\u00e1 \u010das\u0165 psiloc\u00ednu sa najprv metabolizuje v pe\u010deni - nie v \u00fastach alebo \u017eal\u00fadku.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Na druhej strane, ke\u010f sa psilocyb\u00ednov\u00e1 f\u00f3lia roztop\u00ed pod jazykom, m\u00f4\u017ee presko\u010di\u0165 obvykl\u00fa cestu, ktorou sa dost\u00e1va k \"biologickej dostupnosti\". <em>(alebo absorbovan\u00e9 a vyu\u017eit\u00e9 telom),<\/em> do krvn\u00e9ho obehu.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jukka Karjalainen, hlavn\u00fd lek\u00e1r spolo\u010dnosti Cybin, povedal:<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><p> <em>\"Pri peror\u00e1lnom filmovom d\u00e1vkovan\u00ed sa biologick\u00e1 dostupnos\u0165 zvy\u0161uje na 100%. D\u00e1vka, ktor\u00e1 sa pod\u00e1va, je d\u00e1vka dostupn\u00e1 pre klinick\u00fd \u00fa\u010dinok.\" <\/em><\/p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-is-your-gut-required-for-psilocybin-s-full-effect\"> <em>Je pre pln\u00fd \u00fa\u010dinok psilocyb\u00ednu potrebn\u00e9 va\u0161e \u010drevo? <\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Vydr\u017ete. Ak je d\u00e1vka pod\u00e1van\u00e1 prostredn\u00edctvom or\u00e1lne rozpustn\u00e9ho filmu len zlomkom d\u00e1vky potrebnej pri kapsul\u00e1ch, ak\u00fa \u00falohu potom e\u0161te zohr\u00e1vaj\u00fa \u010drev\u00e1, pokia\u013e ide o psilocyb\u00edn? Dr. Alan Davis, odborn\u00fd asistent oddelenia psychedelick\u00e9ho v\u00fdskumu Univerzity Johna Hopkinsa, pon\u00faka nieko\u013eko inform\u00e1ci\u00ed:<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><p> <em>\"Existuje tie\u017e ist\u00e1 pochybnos\u0165 o v\u00fdzname \u010driev pri naru\u0161en\u00ed procesov du\u0161evn\u00e9ho zdravia.\"<\/em><\/p><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Davis tie\u017e uviedol, \u017ee \u010drevn\u00fd mikrobi\u00f3m - teda s\u00fahrn bakt\u00e9ri\u00ed, prvokov a h\u00fab, ktor\u00e9 sa vo v\u00e1s nach\u00e1dzaj\u00fa - m\u00f4\u017ee zohr\u00e1va\u0165 \u00falohu v du\u0161evnom zdrav\u00ed. Je to sp\u00f4soben\u00e9 najm\u00e4 mno\u017estvom seroton\u00ednov\u00fdch transport\u00e9rov <em>(ktor\u00fd prin\u00e1\u0161a psiloc\u00edn do mozgu)<\/em> vo vn\u00fatri \u010dreva.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-this-could-mean-for-patients\"><em>\u010co to m\u00f4\u017ee znamena\u0165 pre pacientov<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tenk\u00e9 pl\u00e1tky IntelGenX <a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/www.intelgenx.com\/technology\/versafilm.html\" target=\"_blank\" rel=\"noreferrer noopener\">Technol\u00f3gia VersaFilm<\/a> - ktor\u00fd umo\u017e\u0148uje r\u00fdchly rozpad bez potreby vody - m\u00e1 ve\u013ea d\u00f4sledkov nielen pre psychedelik\u00e1, ale pre medic\u00ednu v\u0161eobecne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Univerz\u00e1lna platforma na pod\u00e1vanie liekov, ako s\u00fa filmov\u00e9 p\u00e1siky, by mohla pacientom poskytn\u00fa\u0165 mno\u017estvo \u010fal\u0161\u00edch potenci\u00e1lnych v\u00fdhod, ako napr:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>R\u00fdchlej\u0161ia buk\u00e1lna absorpcia<\/strong> <em>(\u010do znamen\u00e1, \u017ee sa liek umiestni medzi \u010fasn\u00e1 a l\u00edce).<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>R\u00fdchlej\u0161ia sublingv\u00e1lna absorpcia<\/strong> <em>(\"pod jazykom<\/em>.&#8221;<em>)<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>R\u00fdchlej\u0161\u00ed n\u00e1stup \u00fa\u010dinku + zv\u00fd\u0161en\u00e1 biologick\u00e1 dostupnos\u0165<\/strong>.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>V\u00e4\u010d\u0161ie pohodlie pre pacientov<\/strong> v\u010faka svojej malej a tenkej ve\u013ekosti.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tie\u017e vynechan\u00edm metabolizmu prv\u00e9ho prechodu, <em>\"\u010do si d\u00e1vkujete, to aj dostanete\"<\/em> - tak\u017ee je tu <strong>viac liekov na vstrebanie do krvn\u00e9ho obehu<\/strong> <em>(na rozdiel od kaps\u00fal)<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Filmov\u00e9 p\u00e1sy s\u00fa tie\u017e ide\u00e1lne pre pacientov, ktor\u00ed maj\u00fa probl\u00e9my s preh\u013atan\u00edm, ob\u00e1vaj\u00fa sa udusenia alebo ich tr\u00e1pi nevo\u013enos\u0165 z<strong> chemoterapia<\/strong> alebo <strong>r\u00e1dioterapia<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Existuje tie\u017e mo\u017enos\u0165 neobmedzen\u00fdch chu\u0165ov\u00fdch mo\u017enost\u00ed, preto\u017ee cel\u00fd pr\u00edjem sa uskuto\u010d\u0148uje v chu\u0165ov\u00fdch poh\u00e1rikoch. <em>(Filmov\u00e9 p\u00e1siky s pr\u00edchu\u0165ou m\u00e4tovej \u010dokol\u00e1dy? Cybin by bol bl\u00e1zon, keby neexperimentoval)<\/em>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials-in-jamaica\"><em>Klinick\u00e9 sk\u00fa\u0161ky na Jamajke<\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Spolo\u010dnos\u0165 Cybin m\u00e1 v \u00famysle uskuto\u010dni\u0165 svoje sk\u00fa\u0161ky na Jamajke, jednom zo \u0161\u0165astn\u00fdch miest, kde je psilocyb\u00edn leg\u00e1lny, a to celkovo v dvoch f\u00e1zach: F\u00e1za2A a F\u00e1za2B. F\u00e1za 2A by mala presne zisti\u0165, ko\u013eko miligramov \u010dist\u00e9ho psilocyb\u00ednu <em>(pod\u00e1van\u00e9 sublingv\u00e1lne prostredn\u00edctvom filmov\u00fdch p\u00e1sikov)<\/em> zodpoved\u00e1 \u0161tandardnej d\u00e1vke 25 mg v kapsule. Konkr\u00e9tne sa bud\u00fa testova\u0165 d\u00e1vky 1, 3, 5 a 7 mg. Vo f\u00e1ze 2B sa potom bude testova\u0165 spr\u00e1vna sublingv\u00e1lna d\u00e1vka oproti placebu u 120 \u00fa\u010dastn\u00edkov s ve\u013ekou depres\u00edvnou poruchou <em>(MDD)<\/em>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-easier-times-ahead-for-patients-and-their-caregivers\"><em> \u010cakaj\u00fa pacientov a ich opatrovate\u013eov \u013eah\u0161ie \u010dasy? <\/em><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Jednoduchos\u0165, pohodlie a komfort.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To s\u00fa veci, ktor\u00e9 niekedy m\u00f4\u017eeme pova\u017eova\u0165 za samozrejm\u00e9. Te\u0161\u00edme sa z jednoduch\u00fdch \u017eivotn\u00fdch radost\u00ed, ako je napr\u00edklad \u0161tvr\u0165pult so syrom alebo \u013eadovo vychladen\u00e9 pivo. M\u00e1me luxus \u010dasu, luxus, ktor\u00fd si pacienti v <a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/www.who.int\/cancer\/palliative\/definition\/en\/\" target=\"_blank\" rel=\"noreferrer noopener\">paliat\u00edvna starostlivos\u0165<\/a> nemusia by\u0165 poskytnut\u00e9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Preto je pre vedcov tak\u00e1 d\u00f4le\u017eit\u00e1 inov\u00e1cia, pre psychedelick\u00fd v\u00fdskum <em>(alebo len lek\u00e1rsky v\u00fdskum vo v\u0161eobecnosti)<\/em> usilova\u0165 sa o to, aby boli sk\u00fasenosti t\u00fdchto pacientov znesite\u013enej\u0161ie.  Jednoduch\u00e9 veci, ako napr\u00edklad skr\u00e1tenie \u010dakacej doby, by mohli u\u0161etri\u0165 cenn\u00e9 sekundy z ka\u017edodennej rutiny pacienta - ktor\u00e9 by mal str\u00e1vi\u0165 v pohodl\u00ed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">T\u00e1to nov\u00e1 technol\u00f3gia psilocyb\u00ednov\u00fdch pr\u00fa\u017ekov je \u010fal\u0161\u00edm krokom k legit\u00edmnosti a efekt\u00edvnosti psychedelickej lie\u010dby... bude hra\u0165 d\u00f4le\u017eit\u00fa \u00falohu v medic\u00edne bud\u00facnosti, najm\u00e4 pri starostlivosti o pacientov na konci \u017eivota.&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Pr\u00eds\u013eub psychedelick\u00fdch l\u00e1tok \u017eiari jasnej\u0161ie s ka\u017ed\u00fdm \u010fal\u0161\u00edm objavom vo v\u00fdskume. Vezmime si napr\u00edklad terapiu MDMA pre pacientov s posttraumatickou stresovou poruchou alebo mikrod\u00e1vkovanie psilocyb\u00ednu na boj proti depresii a \u00fazkosti. A spom\u00ednate si, ke\u010f Kanada povolila u\u017e\u00edvanie psilocyb\u00ednu pri starostlivosti na konci \u017eivota?\u00a0<\/p>","protected":false},"author":1,"featured_media":14865,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[],"topics":[],"class_list":["post-14862","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-culture"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/14862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/comments?post=14862"}],"version-history":[{"count":1,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/14862\/revisions"}],"predecessor-version":[{"id":123816,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/14862\/revisions\/123816"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/media\/14865"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/media?parent=14862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/categories?post=14862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/tags?post=14862"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/topics?post=14862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}