{"id":15803,"date":"2020-10-27T16:31:00","date_gmt":"2020-10-27T16:31:00","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=15165"},"modified":"2023-11-02T13:33:55","modified_gmt":"2023-11-02T12:33:55","slug":"anti-inflammatory-compound-found-in-psychedelics","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/sk\/blog\/protizapalove-zluceniny-najdene-v-psychedelikach\/","title":{"rendered":"Protiz\u00e1palov\u00e1 zl\u00fa\u010denina n\u00e1jden\u00e1 v psychedelik\u00e1ch"},"content":{"rendered":"<\/p>\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-anti-inflammatory-compound-found-in-psychedelics\"><em>Protiz\u00e1palov\u00e1 zl\u00fa\u010denina n\u00e1jden\u00e1 v psychedelik\u00e1ch<\/em><\/h2>\n\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Siln\u00e9 psychedelick\u00e9 zl\u00fa\u010deniny, ako napr.&nbsp;<a href=\"https:\/\/staging.wholecelium.com\/sk\/wiki\/mykologia-2\/co-je-psilocybin-2\/\" target=\"_blank\" rel=\"noopener\">psilocyb\u00edn<\/a>&nbsp;<em>(z <strong>magick\u00e9 huby<\/strong>)<\/em>, <strong>DMT<\/strong> a <strong>LSD<\/strong> z\u00edskali v posledn\u00fdch rokoch podporu vedy. Bolo publikovan\u00fdch mnoho v\u00fdskumov, ktor\u00e9 presne ukazuj\u00fa.<strong> ako m\u00f4\u017eu psychedelik\u00e1 p\u00f4sobi\u0165 protiz\u00e1palovo<\/strong>.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Teraz v\u00fdskumn\u00edci z<strong> Centrum zdravotn\u00edckych vied Louisianskej \u0161t\u00e1tnej univerzity<\/strong> objavili zl\u00fa\u010deninu naz\u00fdvan\u00fa <strong>2C-H<\/strong>. Pri testoch sa zistilo, \u017ee t\u00e1to l\u00e1tka m\u00e1 najlep\u0161ie protiz\u00e1palov\u00e9 v\u00fdsledky. Uk\u00e1zalo sa, \u017ee 2C-H je na molekul\u00e1rnej \u00farovni ve\u013emi podobn\u00fd psychedelickej droge 2C-B<em>. <\/em><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-there-s-always-space-for-serotonin\"><em>Pre seroton\u00edn sa v\u017edy n\u00e1jde miesto<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Psychedelick\u00e9 drogy vyvol\u00e1vaj\u00fa svoj po\u017eadovan\u00fd \u00fa\u010dinok na mozog t\u00fdm, \u017ee sa prip\u00e1jaj\u00fa k <strong>seroton\u00ednov\u00fd receptor<\/strong> v mozgu, ktor\u00fd sa naz\u00fdva <strong><a href=\"https:\/\/en.wikipedia.org\/wiki\/5-HT_receptor\" target=\"_blank\" rel=\"noreferrer noopener\">5HT-2A<\/a><\/strong>.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\">Seroton\u00edn<\/a><\/strong>, zn\u00e1my ako \"horm\u00f3n \u0161\u0165astia\", zni\u017euje z\u00e1pal v imunitn\u00fdch bunk\u00e1ch tela. Preto \u010d\u00edm viac seroton\u00ednu sa vylu\u010duje, t\u00fdm lep\u0161ie pre pacientov so stavmi, ako s\u00fa napr. <strong>astma<\/strong> a<strong> artrit\u00edda<\/strong>.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-now-think-of-psychedelics-as-a-substitute-for-serotonin\"><em>Myslite teraz na psychedelik\u00e1 ako na n\u00e1hradu seroton\u00ednu&nbsp;<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Podobne ako seroton\u00edn, aj psychedelick\u00e9 drogy vyvol\u00e1vaj\u00fa receptor 5HT-2A. L\u00e1tky ako psilocyb\u00edn teda m\u00f4\u017eu pom\u00f4c\u0165 zn\u00ed\u017ei\u0165 aj z\u00e1pal. Ale tu je t\u00e1 zvl\u00e1\u0161tna \u010das\u0165. 2C-H - hoci je pr\u00edtomn\u00fd v psychedelick\u00fdch l\u00e1tkach - s\u00e1m o sebe nem\u00e1 absol\u00fatne \u017eiadne psychoakt\u00edvne \u00fa\u010dinky...<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-2c-h-a-psychedelic-compound-without-the-high\"><em>2C-H: psychedelick\u00e1 zl\u00fa\u010denina bez opojenia <\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"406\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-1024x406.png\" alt=\"diagram potkanov s vidite\u013en\u00fdmi p\u013e\u00facami ukazuje protiz\u00e1palov\u00e9 vlastnosti 2-CH\" class=\"wp-image-159637\" srcset=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-1024x406.png 1024w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-600x238.png 600w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-300x119.png 300w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-768x305.png 768w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-1536x609.png 1536w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram-18x7.png 18w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-rats-diagram.png 1720w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em>Vedci potvrdili \u00fa\u010dinnos\u0165 2-CH na modeli astmy u potkanov. V\u0161imnite si, \u017ee protiz\u00e1palov\u00fd aspekt 2-CH p\u00f4sob\u00ed oddelene od \"trippy\" efektu. To otv\u00e1ra mo\u017enos\u0165 \"netripov\u00e9ho\" z\u00e1\u017eitku pre pacientov s astmou, ktor\u00ed v s\u00fa\u010dasnosti u\u017e\u00edvaj\u00fa psilocyb\u00edn na \u00fa\u013eavu.<\/em> <strong>Fotografia s l\u00e1skav\u00fdm dovolen\u00edm: ACS Pharmacol.<\/strong><\/figcaption><\/figure>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Vedci testovali 21 r\u00f4znych zl\u00fa\u010den\u00edn na potkanoch s pr\u00edznakmi astmy.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\"><em>(Toto bolo vykonan\u00e9 s cie\u013eom overi\u0165, \u010di existuje nejak\u00e1 s\u00favislos\u0165 medzi <strong>\"kanonick\u00e9 sign\u00e1lne dr\u00e1hy\"<\/strong> ktor\u00fd sa postar\u00e1 o \"trippy\" \u010das\u0165 a po\u017eadovan\u00fd protiz\u00e1palov\u00fd \u00fa\u010dinok.)<\/em><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Ke\u010f\u017ee v\u0161etky psychedelick\u00e9 zl\u00fa\u010deniny aktivovali receptor 5HT-2A, mnoh\u00e9 z nich dok\u00e1zali zabr\u00e1ni\u0165 <em>(a dokonca aj opa\u010dne)<\/em> z\u00e1pal v p\u013e\u00facach. A h\u00e1dajte \u010do? Protiz\u00e1palov\u00e9 \u00fa\u010dinky 2-CH v\u00f4bec nekoreluj\u00fa s \"behavior\u00e1lnou aktivitou\" alebo vybo\u010den\u00edm... v\u00f4bec.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\"><em>\"Psychedelick\u00e9 drogy m\u00f4\u017eu ma\u0165 [siln\u00fd] protiz\u00e1palov\u00fd \u00fa\u010dinok. Zd\u00e1 sa v\u0161ak, \u017ee protiz\u00e1palov\u00e9 \u00fa\u010dinky nekoreluj\u00fa s behavior\u00e1lnou aktivitou, \u010do nazna\u010duje r\u00f4zne z\u00e1kladn\u00e9 mechanizmy.\" <\/em><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">- z <strong>ACS Pharmacology &amp; Translational Science (2020) <\/strong><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-testing-2c-h-for-inflammation-in-allergic-asthma\"><em>Testovanie 2C-H na z\u00e1pal pri alergickej astme<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">21 <strong>agonistov<\/strong> <em>(alebo lieky, ktor\u00e9 sa via\u017eu na receptor a aktivuj\u00fa ho)<\/em> boli vybran\u00e9 z 3 prim\u00e1rnych chemotypov na z\u00e1klade ich schopnosti predch\u00e1dza\u0165 pr\u00edznakom astmy.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Niektor\u00e9 z t\u00fdchto pr\u00edznakov zah\u0155\u0148aj\u00fa:<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<ul class=\"wp-block-list\">\n<li><strong>D\u00fdchavi\u010dnos\u0165<\/strong><\/li>\n<li><strong>Tlak alebo boles\u0165 na hrudn\u00edku<\/strong><\/li>\n<li><strong>Sipot pri v\u00fddychu (\u010dast\u00fd u astmatick\u00fdch det\u00ed)<\/strong><\/li>\n<li><strong>Probl\u00e9my so sp\u00e1nkom sp\u00f4soben\u00e9 d\u00fdchavi\u010dnos\u0165ou, ka\u0161\u013eom alebo sipotom<\/strong><\/li>\n<\/ul>\n<p>\n\n\n<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"735\" height=\"1024\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-735x1024.png\" alt=\"Sn\u00edmky p\u013e\u00fac potkanov, ktor\u00e9 ukazuj\u00fa, ako m\u00f4\u017ee 2-CH zabr\u00e1ni\u0165 z\u00e1palu a nadprodukcii hlienu. \" class=\"wp-image-159641\" srcset=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-735x1024.png 735w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-600x835.png 600w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-215x300.png 215w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-768x1069.png 768w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH-9x12.png 9w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/Anti-inflammatory-scans-of-rat-lungs-2-CH.png 958w\" sizes=\"(max-width: 735px) 100vw, 735px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Inhal\u00e1cia 2C-H m\u00f4\u017ee pom\u00f4c\u0165 predch\u00e1dza\u0165 z\u00e1palu a nadprodukcii hlienu. Na obr\u00e1zku s\u00fa skuto\u010dn\u00e9 d\u00fdchacie cesty \"astmatick\u00fdch\" potkanov (lie\u010den\u00fdch 2C-H). Fotografia je s l\u00e1skav\u00fdm dovolen\u00edm: ACS Pharmacol.<\/mark><\/em><\/figcaption><\/figure>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Vedci zistili, \u017ee 2-CH je \"najakt\u00edvnej\u0161ou\" \u010das\u0165ou molekulovej \u0161trukt\u00fary pre protiz\u00e1palov\u00fa aktivitu.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Pozornos\u0165 venovan\u00e1 2CH by mohla skr\u00e1ti\u0165 preteky farmaceutick\u00fdch spolo\u010dnost\u00ed, ktor\u00e9 sa teraz sna\u017eia <strong>vlna psychedel\u00edk v hlavnom pr\u00fade<\/strong>. Teraz u\u017e vedia, na ktor\u00fa chemick\u00fa l\u00e1tku sa m\u00f4\u017eu zamera\u0165.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-what-this-could-mean-for-anti-inflammatory-drugs-in-the-future\"><em>\u010co to m\u00f4\u017ee znamena\u0165 pre protiz\u00e1palov\u00e9 lieky v bud\u00facnosti<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">V s\u00fa\u010dasnosti je mnoho \u013eud\u00ed bez pe\u0148az\u00ed kv\u00f4li pand\u00e9mii COVID19. Okrem straty pr\u00edjmu z d\u00f4vodu pr\u00e1ceneschopnosti sa mnoh\u00ed ocitli aj mimo zdravotn\u00e9ho poistenia.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Udr\u017eiavacie lieky na chronick\u00e9 ochorenia, ako je astma, nie s\u00fa lacn\u00e9 - predp\u00edsan\u00e9 inhal\u00e1tory stoja najmenej <strong>$496<\/strong> <strong>ka\u017ed\u00fd<\/strong>. Na\u0161\u0165astie lek\u00e1ri teraz postupne zva\u017euj\u00fa<strong> <a href=\"https:\/\/www.healtheuropa.eu\/psychedelics-association-to-bridge-medical-establishment-and-industry-gap\/102885\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\">psychedelick\u00e9 mo\u017enosti pre svojich pacientov<\/a><\/strong>.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Ned\u00e1vny objav 2-CH by mohol v bl\u00edzkej bud\u00facnosti znamena\u0165 mno\u017estvo nov\u00fdch n\u00e1vrhov protiz\u00e1palov\u00fdch liekov.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Sledujte tento priestor!<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">&nbsp;<\/p>\n<p>\n\n\n<\/p>","protected":false},"excerpt":{"rendered":"<p>Aj ke\u010f to be\u017en\u00e9mu u\u017e\u00edvate\u013eovi nemus\u00ed by\u0165 jasn\u00e9, vedci u\u017e nejak\u00fd \u010das sk\u00famaj\u00fa potenci\u00e1lne protiz\u00e1palov\u00e9 vlastnosti psychedelick\u00fdch drog. Ich v\u00fdskum teraz jasne uk\u00e1zal, \u017ee psychedelik\u00e1 m\u00f4\u017eu pom\u00f4c\u0165 v boji proti z\u00e1palom v tele.\u00a0<\/p>","protected":false},"author":1,"featured_media":15818,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-15803","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/15803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/comments?post=15803"}],"version-history":[{"count":6,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/15803\/revisions"}],"predecessor-version":[{"id":159643,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/15803\/revisions\/159643"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/media\/15818"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/media?parent=15803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/categories?post=15803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/tags?post=15803"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sk\/wp-json\/wp\/v2\/topics?post=15803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}