{"id":16462,"date":"2020-12-18T09:12:03","date_gmt":"2020-12-18T09:12:03","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=16462"},"modified":"2023-11-02T15:41:30","modified_gmt":"2023-11-02T14:41:30","slug":"first-dmt-trial-for-major-depression","status":"publish","type":"post","link":"https:\/\/staging.wholecelium.com\/sl\/blog\/prvi-dmt-trial-za-veliko-depresijo\/","title":{"rendered":"Prvo presku\u0161anje DMT za hudo depresijo"},"content":{"rendered":"<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Poznan tudi kot <strong>N,N-dimetiltriptamin<\/strong>, DMT je znan po intenzivnih potovanjih, ki vodijo globoko v duhovno divjino. \u010ceprav je DMT mogo\u010de najti v ve\u010dini rastlin in \u017eivali, je njegova slava povezana z <strong>Ayahuasca<\/strong> - psihedeli\u010dni \u010daj iz istoimenske amazonske trte. Lokalna plemena v Amazoniji \u017ee ve\u010d sto let pijejo DM-Tea. <em>(razumete?)<\/em> za zdravljenje bolezni uma, telesa in du\u0161e.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Ali je \u017ee skrajni \u010das za preu\u010devanje DMT s pravimi \u017eivimi bolniki? Morda pripraviti pot za njegovo zakonito in raz\u0161irjeno uporabo? Izvedeli bomo!<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-lasting-changes-in-brain-function\"><em>Trajne spremembe delovanja mo\u017eganov <\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">\u017de en odmerek ayahuasce lahko povzro\u010di trajne spremembe v delovanju mo\u017eganov. Oseba, ki je na primer nagnjena k trmoglavosti, postane odprta za spremembe. Ta t. i. <em>\"pro\u017enost mo\u017eganov\"<\/em> ki ga povzro\u010da DMT, lahko tudi<strong>&nbsp;<\/strong><a href=\"https:\/\/staging.wholecelium.com\/sl\/blog\/dmt-za-depresijo-odporno-na-zdravljenje\/\" target=\"_blank\" rel=\"noopener\"><b>spreminjanje simptomov depresije.<\/b><\/a><strong>.  <\/strong><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Toda to je ayahuasca, katere u\u010dinki lahko trajajo do 8 ur. Po drugi strani pa, <strong>\u010disti DMT<\/strong> <em>(kadjene ali vbrizgane)<\/em>, traja le pribli\u017eno 15 do 30 minut. Potovanja z DMT so lahko kratka, vendar so noro mo\u010dna. <em>Napoleonova<\/em>, celo.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Raziskovalci z Univerze Johns Hopkins so ugotovili, da je 90% tistih, ki so poskusili DMT, dejalo, da so bolj zadovoljni s svojim \u017eivljenjem, 80% pa, da je njihovo potovanje z DMT <strong>za vedno spremenil njihov pogled na resni\u010dnost.<\/strong>... kot v Matrici.<\/p>\n<p>\n\n\n<\/p>\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"639\" height=\"356\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1.jpg\" alt=\"\u017eare\u010da mo\u017eganska sinapsa\" class=\"wp-image-159727\" style=\"width:841px\" srcset=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1.jpg 639w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1-600x334.jpg 600w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1-300x167.jpg 300w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/glowing-brain-synapse-1-18x10.jpg 18w\" sizes=\"(max-width: 639px) 100vw, 639px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">prek Unsplasha<\/mark><\/em><\/figcaption><\/figure>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-faster-than-expected\"> <em>Hitreje, kot je bilo pri\u010dakovati<\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Raziskava, ki je v prvi fazi hitreje, kot je bilo pri\u010dakovano, je rezultat sodelovanja med <strong>Imperial College London<\/strong> in . <strong>Mala farmacija<\/strong>, ki se ukvarja z zdravljenjem mo\u017eganov.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Izvr\u0161ni direktor podjetja Small Pharma <strong>Peter Rands<\/strong> je dejal:<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\"><em>\"DMT zagotavlja psihedeli\u010dno izku\u0161njo v 20 minutah in ima edinstvene lastnosti. Upamo, da bomo s sprejetjem odgovornih raziskav, ki temeljijo na dokazih ..., pomagali ponovno uveljaviti te neko\u010d stigmatizirane spojine kot zelo u\u010dinkovite medicinske terapije.\"<\/em><\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">\u010ce se izka\u017ee za uspe\u0161no, bi ta poskus DMT lahko \u0161e pove\u010dal mo\u017enost vklju\u010ditve zdravil na osnovi psihedelikov v na\u0161 zdravstveni sistem.  To pomeni. <strong>cenej\u0161e, bolj naravne mo\u017enosti<\/strong> za milijone ljudi, ki trpijo za depresijo. Dr\u017eimo pesti!<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-healthy-volunteers-first\"> <em>Najprej zdravi prostovoljci <\/em><\/h2>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Faza 1 se bo za\u010dela januarja 2021. V tej fazi bodo DMT testirali na zdravih prostovoljcih. <em>(ki \u0161e nikoli niso poskusili psihedelikov)<\/em> prvi.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Na ta na\u010din lahko \u0161tudija <strong>kontrolna skupina<\/strong> za primerjavo z bolniki z depresijo <em>(znana tudi kot faza 2a)<\/em>. Seveda je treba za tak\u0161ne prostovoljce, ki trpijo zaradi tak\u0161nih iz\u010drpavajo\u010dih bolezni, vzpostaviti mre\u017eo podpore - tako dru\u017ebeno kot znanstveno.&nbsp;<\/p>\n<p>\n\n\n<\/p>\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"432\" src=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-1024x432.jpeg\" alt=\"\u010darobne gobe na barvitem spiralnem ozadju\" class=\"wp-image-159730\" srcset=\"https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-1024x432.jpeg 1024w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-600x253.jpeg 600w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-300x127.jpeg 300w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-768x324.jpeg 768w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-1536x648.jpeg 1536w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21-18x8.jpeg 18w, https:\/\/staging.wholecelium.com\/wp-content\/uploads\/bald-head-swirl-background-21.jpeg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-2021-the-year-of-legalization\"><em> 2021: Leto legalizacije? <\/em><\/h2>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">DMT in psilocibin lahko obravnavamo kot bli\u017enja sorodnika, saj sta oba <strong><a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/tryptamines\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\">triptamini<\/a><\/strong>, kar pomeni, da imata enako \u0161iroko molekularno dru\u017eino. Tako DMT kot psilocibin \u0161\u010demita \u017eiv\u010dne kon\u010di\u010de v mo\u017eganih in povzro\u010data spremenjeno stanje zavesti. Vendar ima le psilocibin zakonsko dovoljenje. <em>(vsaj v Oregonu - kmalu bodo sledile \u0161e druge dr\u017eave)<\/em>. Kaj je torej narobe?<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Tukaj so podatki.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Pred Oregonom <a href=\"https:\/\/staging.wholecelium.com\/sl\/articles\/psychedelic-culture\/oregon-votes-yes-to-psilocybin\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>odobreno<\/strong> <\/a>pri terapevtski uporabi psilocibina se spojina najprej <em>\"zmagal\"<\/em> v o\u010deh raziskovalcev + velike univerze, kot so <strong>John Hopkins<\/strong>. Poskusi s psilocibinom so prinesli trdne dokaze, da je z njim mogo\u010de zdraviti odporno depresijo... <em>(zmaga)<\/em> pravni argument. Pravni precedens pa ni majhna stvar.<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<p class=\"wp-block-paragraph\">Zdi se, da je DMT naslednji veliki psihedelik, ki mu je treba slediti, glede na njegovo trenutno pot. In kdo ve? Tokrat, konec leta 2021, bo DMT morda tudi zakonsko odobren...<\/p>\n<p>\n\n\n<\/p>\n\n\n<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/B411rHX7nUZjyljr7huxKnin5wuIztfKmCoE9dAVhr3jvODq9nCysQgz6gIkCa2W443VcbaOszqq59L-mOhEW7eYQjakpnGaayDRKn0SQExl_Nuzf-ct0ZX8Y91by-IMnHoaZQ2X\" alt=\"\"><\/figure>\n<p>\n\n\n\n\n\n\n<\/p>","protected":false},"excerpt":{"rendered":"<p>Psihonauti ga \u017ee dolgo \u010dastijo, zdaj pa je \u010das, da ga dohiti tudi preostali svet ... Januarja 2021, torej \u010dez nekaj tednov, se bodo prvi\u010d v zgodovini za\u010deli klini\u010dni poskusi z DMT na bolnikih. Raziskovalci iz Zdru\u017eenega kraljestva bodo enkrat za vselej dokazali, da je tako imenovana \"molekula duha\" legitimno zdravilo za zdravljenje hude depresije ... in dostojen tekmec za enega najmo\u010dnej\u0161ih psihedelikov na svetu.\u00a0<\/p>","protected":false},"author":1,"featured_media":17812,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-16462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/posts\/16462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/comments?post=16462"}],"version-history":[{"count":7,"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/posts\/16462\/revisions"}],"predecessor-version":[{"id":159735,"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/posts\/16462\/revisions\/159735"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/media\/17812"}],"wp:attachment":[{"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/media?parent=16462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/categories?post=16462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/tags?post=16462"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/staging.wholecelium.com\/sl\/wp-json\/wp\/v2\/topics?post=16462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}